{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T11:02:34Z","timestamp":1790679754330,"version":"4.1.0"},"reference-count":19,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biomedical Materials Res"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Immune checkpoint inhibitors have shown limited efficacy in bladder cancer due to the immunosuppressive tumor microenvironment. To address this challenge, we developed a \u03b2\u2010lapachone\u2010loaded iron\u2010based carbon nanozyme (C\u2010MIL@Lapa) that synergistically induces ferroptosis and immunogenic cell death (ICD). Carbonized MIL\u2010100(Fe) (C\u2010MIL) serves as both a drug carrier and a nanozyme with dual peroxidase and glutathione oxidase activities. In tumor cells, \u03b2\u2010lapachone generates endogenous H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    via NQO1\u2010mediated redox cycling, which is then converted into cytotoxic hydroxyl radicals by C\u2010MIL. This cascade reaction causes glutathione depletion and lipid peroxidation, leading to ferroptosis. Meanwhile, ferroptotic cell death releases damage\u2010associated molecular patterns that trigger ICD, activating dendritic cells and CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cell\u2010mediated antitumor immunity. In\u00a0vitro and in\u00a0vivo results demonstrated that C\u2010MIL@Lapa significantly inhibited bladder cancer growth and remodeled the tumor immune microenvironment. This work provides a nanozyme\u2010based strategy for synergistic ferroptosis\u2010immunotherapy of bladder cancer with promising clinical potential.\n                  <\/jats:p>","DOI":"10.1002\/jbm.a.70164","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T10:36:34Z","timestamp":1790678194000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cascade Catalytic Nanozyme Amplifies Ferroptosis Immunotherapy in Bladder Cancer"],"prefix":"10.1002","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-6774-2174","authenticated-orcid":false,"given":"Hongbo","family":"Luo","sequence":"first","affiliation":[{"name":"Department of Urology Renmin Hospital of Wuhan University  Wuhan Hubei Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Urology Jingshan Union Hospital of Huazhong University of Science and Technology  Jingshan Hubei Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3803-8245","authenticated-orcid":false,"given":"Yang","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Urology Renmin Hospital of Wuhan University  Wuhan Hubei Province 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