{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T14:53:01Z","timestamp":1792162381538,"version":"4.4.0"},"reference-count":63,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005317","name":"Kermanshah University of Medical Sciences","doi-asserted-by":"publisher","award":["4010370"],"award-info":[{"award-number":["4010370"]}],"id":[{"id":"10.13039\/501100005317","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biomedical Materials Res"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Urethral stricture remains a challenging clinical condition, particularly in patients with long or complex defects where suitable donor tissue is limited. Tissue engineering offers a promising alternative through the development of biomimetic scaffolds capable of restoring urethral structure and function. In this study, we fabricated a sandwich nanofibrous scaffold based on polyglycolic acid (PGA) and decellularized urethral extracellular matrix (uECM) using a sandwich design (uECM\/PGA\/uECM) and compared it with PGA and mix (PGA\u2013uECM) scaffolds. Successful decellularization was confirmed by histological and molecular analyses, demonstrating effective removal of cellular components while preserving ECM architecture. Structural characterization revealed high porosity, enhanced hydrophilicity, favorable swelling behavior, and controlled degradation in ECM\u2010containing scaffolds. The uECM\/PGA\/uECM construct exhibited superior mechanical strength while maintaining suitable elasticity for urethral applications. Biological evaluation showed significantly improved endothelial cell adhesion, cell viability, and migration in ECM\u2010integrated scaffolds compared with PGA alone. In\u00a0vivo implantation demonstrated excellent biocompatibility, absence of adverse inflammatory responses, and evident neovascularization. Overall, the sandwich uECM\/PGA\/uECM scaffold combines mechanical stability with bioactive functionality, highlighting its potential as a promising candidate for urethral tissue regeneration.<\/jats:p>","DOI":"10.1002\/jbm.a.70166","type":"journal-article","created":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T06:30:05Z","timestamp":1791441005000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Fabrication and Characterization of Bioengineered Sandwich Model Scaffold for Urethral Stricture Reconstruction"],"prefix":"10.1002","volume":"114","author":[{"given":"Parvin","family":"Mohammadi","sequence":"first","affiliation":[{"name":"Regenerative Medicine Research Center Health Technology Institute, Kermanshah University of Medical Sciences  Kermanshah Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8340-8807","authenticated-orcid":false,"given":"Mina","family":"Habibizadeh","sequence":"additional","affiliation":[{"name":"Regenerative Medicine Research Center Health Technology Institute, Kermanshah University of Medical Sciences  Kermanshah Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4546-5202","authenticated-orcid":false,"given":"Zhila","family":"Izadi","sequence":"additional","affiliation":[{"name":"Pharmaceutical Sciences Research Center Health Institute, Kermanshah University of Medical Sciences  Kermanshah Iran"},{"name":"USERN Office Kermanshah University of Medical Sciences  Kermanshah Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0314-8735","authenticated-orcid":false,"given":"Kamran","family":"Mansouri","sequence":"additional","affiliation":[{"name":"Medical Biology Research Center Health Technology Institute, Kermanshah University of Medical Sciences  Kermanshah Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoudreza","family":"Moradi","sequence":"additional","affiliation":[{"name":"Regenerative Medicine Research Center Health Technology Institute, Kermanshah University of Medical Sciences  Kermanshah Iran"},{"name":"Department of Urology, Imam Reza Hospital Kermanshah University of Medical Sciences  Kermanshah Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,7]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2013.09.009"},{"issue":"1","key":"e_1_2_12_3_1","first-page":"10","article-title":"Dorsal Inlay Buccal Mucosal Graft (Asopa) Urethroplasty for Anterior Urethral Stricture","volume":"4","author":"Marshall S. 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