{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T04:39:26Z","timestamp":1792643966313,"version":"4.5.0"},"reference-count":37,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:00:00Z","timestamp":1792540800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:00:00Z","timestamp":1792540800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004154","name":"Mae Fah Luang University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004154","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biomedical Materials Res"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Injectable self\u2010healing hydrogels represent promising wound dressing materials due to their conformability and minimally invasive application. This study investigated gallic acid (GA)\u2010loaded hydrogels prepared through physical blending of quaternized chitosan (QCS) with GA, followed by mixing with oxidized pectin (OPEC) for crosslinking. The gelation time increased from 34\u2009s to 477\u2009s with increasing GA content while maintaining the gel fraction &gt;\u200970%. However, the self\u2010healing time decreased dramatically from 252\u2009s to 19\u2009s with increasing GA content. Hydrogel swelling and degradation kinetics revealed an initial loss of non\u2010crosslinked components followed by advantageous slow surface erosion. The adhesive strength (0.74\u20131.48\u2009kPa) remained clinically acceptable for all hydrogels. Rheological analysis revealed a decrease in gel strength with increasing GA content. In addition, the compressive strength decreased from 109 to 42 kPa with increasing GA content. The biological evaluation demonstrated good antioxidant activity, excellent cytocompatibility with HDFa cells, exceptional antibacterial activity (&gt;\u200998% reduction against\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>S. aureus<\/jats:italic>\n                    <\/jats:styled-content>\n                    and\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>E. coli<\/jats:italic>\n                    <\/jats:styled-content>\n                    , with the highest efficacy in H\u20100.3GA), and enhanced in\u00a0vitro wound closure with the addition of GA. Therefore, physical blending provides a straightforward approach for incorporating bioactive polyphenols into chitosan\u2010based hydrogels, offering enhanced therapeutic properties through concentration\u2010dependent mechanisms while maintaining the essential characteristics of wound dressings.\n                  <\/jats:p>","DOI":"10.1002\/jbm.a.70167","type":"journal-article","created":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T04:13:16Z","timestamp":1792642396000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Optimized Self\u2010Healing and Antioxidant Hydrogels Based on Gallic Acid\u2013Blended Quaternized Chitosan and Oxidized Pectin for Potential Wound Dressing Applications"],"prefix":"10.1002","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0958-3797","authenticated-orcid":false,"given":"Porntipa","family":"Pankongadisak","sequence":"first","affiliation":[{"name":"School of Science, Mae Fah Luang University  Chiang Rai Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kitipong","family":"Kiti","sequence":"additional","affiliation":[{"name":"School of Science, Mae Fah Luang University  Chiang Rai Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pimpakan","family":"Faijai","sequence":"additional","affiliation":[{"name":"School of Science, Mae Fah Luang University  Chiang Rai Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mueanchan","family":"Chanmontri","sequence":"additional","affiliation":[{"name":"School of Science, Mae Fah Luang University  Chiang Rai Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6012-9808","authenticated-orcid":false,"given":"Lisbeth","family":"Gr\u00f8ndahl","sequence":"additional","affiliation":[{"name":"School of Chemistry and Molecular Biosciences University of Queensland  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2680-7390","authenticated-orcid":false,"given":"Orawan","family":"Suwantong","sequence":"additional","affiliation":[{"name":"School of Science, Mae Fah Luang University  Chiang Rai Thailand"},{"name":"Center for Chemical Innovation for Sustainability (CIS) Mae Fah Luang University  Chiang Rai Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,21]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.4c06156"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2024.1525644"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2023.124984"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurpolymj.2024.113297"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2023.121707"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-823381-8.00009-0"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26134037"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2023.124321"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.3c01401"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24163005"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5RA01911G"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules21070899"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/fsn3.3615"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2025.114973"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2019.115238"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2019.12.037"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2025.141826"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/gels8120806"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2022.120103"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2023.121231"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27238397"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2021.118887"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.polymer.2025.128721"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.2c01143"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2011.11.018"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/separations11010036"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2024.122936"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2021.10.033"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/app.42142"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.3390\/gels7040255"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2024.123179"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2025.1549526"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.14712\/fb2024070010053"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12906\u2010023\u201004067\u20109"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2024.152288"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2020.116826"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2020.09.072"}],"container-title":["Journal of Biomedical Materials Research Part A"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbm.a.70167","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jbm.a.70167","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbm.a.70167","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T04:13:18Z","timestamp":1792642398000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbm.a.70167"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,21]]},"references-count":37,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["10.1002\/jbm.a.70167"],"URL":"https:\/\/doi.org\/10.1002\/jbm.a.70167","archive":["Portico"],"relation":{},"ISSN":["1549-3296","1552-4965"],"issn-type":[{"value":"1549-3296","type":"print"},{"value":"1552-4965","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,21]]},"assertion":[{"value":"2026-04-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70167"}}