{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T05:38:09Z","timestamp":1792647489828,"version":"4.5.0"},"reference-count":47,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:00:00Z","timestamp":1792540800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:00:00Z","timestamp":1792540800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biomedical Materials Res"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    One of many drawbacks of PMMA bone cement used to secure orthopedic implants is that its surface is highly susceptible to bacterial attachment and biofilm formation. In an effort to find alternative materials, we focused on silorane\u2010based polymers previously developed for use in dental composites. Compared to PMMA, this composite has low shrinkage, low exothermic polymerization, low toxicity, and the potential for lower bacterial susceptibility. Building on this dental material's advantages, a novel silorane\u2010based material for orthopedic use was developed utilizing a dual initiation system including a platinum catalyst and a surface\u2010modified yttria alumino\u2010silicate glass filler. In this study, we tested the silorane\u2010based orthopedic biomaterial for any antibacterial properties while using PMMA cement as the control. Using a variety of models, both static and dynamic, we found a 60%\u201378% decrease in\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>S. aureus<\/jats:italic>\n                    <\/jats:styled-content>\n                    adherence (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.0001). In\u00a0order\u00a0to explore the sources of this antibacterial property, we used profilometry, EDS, and contact angle measurement to characterize the two materials' surfaces. In addition, MIC assays of the material's components and bacterial adherence assays on variations in the material's composition led to insight about which components had the largest effect. The properties and characteristics that lowered its bacterial susceptibility were identified as higher hydrophobicity, significantly lower surface roughness, and the presence of residual platinum following catalysis. Inclusion of the platinum\u2010containing chemical initiator had a large effect in reducing bacterial adherence (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.004). A silorane\u2010based epoxy bone cement with substantial intrinsic inhibition of bacterial adherence may offer an effective way to reduce orthopedic periprosthetic infection without increasing antibiotic resistance.\n                  <\/jats:p>","DOI":"10.1002\/jbm.a.70171","type":"journal-article","created":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T04:54:42Z","timestamp":1792644882000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Intrinsic Antimicrobial Properties of a Novel Silorane\u2010Based Material for Orthopedic Applications"],"prefix":"10.1002","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2286-2894","authenticated-orcid":false,"given":"Terence E.","family":"McIff","sequence":"first","affiliation":[{"name":"Orthopedic Research and Education Center, Department of Orthopedic Surgery and Sports Medicine University of Kansas Medical Center  Kansas City Kansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9594-4340","authenticated-orcid":false,"given":"Grahmm A.","family":"Funk","sequence":"additional","affiliation":[{"name":"Orthopedic Research and Education Center, Department of Orthopedic Surgery and Sports Medicine University of Kansas Medical Center  Kansas City Kansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9648-7803","authenticated-orcid":false,"given":"Elizabeth M.","family":"Menuey","sequence":"additional","affiliation":[{"name":"Discipline of Chemistry, Division of Energy, Matter, and Systems University of Missouri\u2010Kansas City  Kansas City Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda J.","family":"Boyle","sequence":"additional","affiliation":[{"name":"Orthopedic Research and Education Center, Department of Orthopedic Surgery and Sports Medicine University of Kansas Medical Center  Kansas City Kansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-3629-2534","authenticated-orcid":false,"given":"Kara A.","family":"Hageman","sequence":"additional","affiliation":[{"name":"Orthopedic Research and Education Center, Department of Orthopedic Surgery and Sports Medicine University of Kansas Medical Center  Kansas City Kansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5505-8619","authenticated-orcid":false,"given":"Kathleen V.","family":"Kilway","sequence":"additional","affiliation":[{"name":"Discipline of Chemistry, Division of Energy, Matter, and Systems University of Missouri\u2010Kansas City  Kansas City Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,21]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1302\/0301\u2010620X.42B1.28"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.5435\/00124635\u2010201005000\u201000006"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11999\u2010010\u20101545\u20108"},{"issue":"3","key":"e_1_2_11_5_1","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/S0030-5898(20)31680-1","article-title":"Diagnosis and Management of the Infected Total Joint Arthroplasty","volume":"22","author":"Cuckler J. 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