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Anti\u2010calcification treatments are being applied to pericardial tissue, durable polymers are being developed that mitigate oxidative degradation and stress cracking, and heart valve tissue engineering has introduced resorbable scaffolds that can develop into stable, functional tissue. In each case, an increasing breadth of strategies is being developed to curb the persistent issue of valve deterioration. This study aimed to synthesize and characterize an ascorbic acid\u2010containing polyurethane to impart antioxidant properties to degradable scaffolds for tissue engineered heart valve (TEHV) replacement. Blends of poly(carbonate\u2010ascorbic acid) urethane (PCAU) and poly(carbonate urethane) urea (PCUU) were fabricated into microporous scaffolds to evaluate the impact of PCAU in\u00a0vitro on mechanics, degradation, cell viability, calcification, bacterial adhesion, and in\u00a0vivo on native tissue response in a juvenile rat subcutaneous model. PCAU blended with PCUU in a 25:75 ratio (PCAU\u201025) had mechanical properties similar to PCUU, while higher concentrations of PCAU were not mechanically robust. PCAU\u201025 showed greater reactive oxygen species (ROS) inhibition and degradation, and reduced calcification and bacterial adhesion in\u00a0vitro. In a juvenile rat subcutaneous model, both PCUU and PCAU\u201025 groups showed negligible calcification after 4\u2009weeks. PCAU\u201025, however, showed much greater cell infiltration and immune response, possibly due to an accelerated rate of degradation. PCAU\u201025 was then fabricated into a polymeric valve scaffold and underwent basic mechanical and hydrodynamic performance assessment that demonstrated function similar to PCUU valves previously reported. These findings demonstrate proof\u2010of\u2010concept for a new polyurethane formulation incorporating ascorbic acid for antioxidant bioactivity and translatability into a functional TEHV scaffold.<\/jats:p>","DOI":"10.1002\/jbm.a.70172","type":"journal-article","created":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T04:29:53Z","timestamp":1792643393000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["An Ascorbic\u2010Acid Containing Poly(Carbonate) Urethane With Antioxidant Bioactivity for Application in Heart Valve Scaffold Development"],"prefix":"10.1002","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9378-3731","authenticated-orcid":false,"given":"Drake D.","family":"Pedersen","sequence":"first","affiliation":[{"name":"Department of Bioengineering University of Pittsburgh  Pittsburgh Pennsylvania USA"},{"name":"McGowan Institute for Regenerative Medicine University of Pittsburgh  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