{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T04:41:48Z","timestamp":1792644108504,"version":"4.5.0"},"reference-count":30,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:00:00Z","timestamp":1792540800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:00:00Z","timestamp":1792540800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biomedical Materials Res"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Pressure ulcers (PUs) are chronic wounds driven by persistent inflammation, oxidative stress, impaired angiogenesis, and delayed remodeling, yet current treatments remain suboptimal. Here, we developed a novel nanocomposite (CCH) by loading cerium oxide (CeO\n                    <jats:sub>2<\/jats:sub>\n                    ) and curcumin into hollow mesoporous silica nanoparticles (HMSN). CCH exhibited well\u2010defined spherical morphology, favorable particle size, and pH\u2010dependent drug release. Mechanistically, CCH possessed potent superoxide dismutase (SOD)\u2010 and catalase (CAT)\u2010mimetic activities, effectively scavenging reactive oxygen species. In\u00a0vitro, CCH was efficiently internalized by HUVECs, showed excellent biocompatibility up to 100\u2009\u03bcg\/mL, protected HUVECs from oxidative damage by reducing intracellular ROS and restoring VEGF secretion, and induced anti\u2010inflammatory M2 macrophage polarization. In a mouse model of pressure ulcer, topical CCH application significantly accelerated wound closure, enhanced re\u2010epithelialization and granulation tissue formation, reduced systemic CRP and PCT levels, and improved scar prognosis, associated with increased VEGF expression and CD31\u2010positive vascularization, along with organized collagen deposition. Collectively, CCH integrates antioxidant, anti\u2010inflammatory, pro\u2010angiogenic, and tissue\u2010remodeling functions into a single nanoplatform, effectively addressing key pathological features of PUs. Thus, CCH represents a promising and safe candidate for chronic wound management.\n                  <\/jats:p>","DOI":"10.1002\/jbm.a.70174","type":"journal-article","created":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T04:24:12Z","timestamp":1792643052000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Triple\u2010Functional Nanoplatform for Oxidative Stress\u2010Driven Pressure Ulcer Therapy"],"prefix":"10.1002","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0993-2640","authenticated-orcid":false,"given":"Rongxiang","family":"Sun","sequence":"first","affiliation":[{"name":"Emergency and Disaster Medicine Center, the Seventh Affiliated Hospital, Sun Yat\u2010sen University  Shenzhen Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9689-0468","authenticated-orcid":false,"given":"Youting","family":"Hu","sequence":"additional","affiliation":[{"name":"Emergency and Disaster Medicine Center, the Seventh Affiliated Hospital, Sun Yat\u2010sen University  Shenzhen Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9880-3487","authenticated-orcid":false,"given":"Qingyan","family":"Li","sequence":"additional","affiliation":[{"name":"Emergency and Disaster Medicine Center, the Seventh Affiliated Hospital, Sun Yat\u2010sen University  Shenzhen Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianlan","family":"Huang","sequence":"additional","affiliation":[{"name":"Emergency and Disaster Medicine Center, the Seventh Affiliated Hospital, Sun Yat\u2010sen University  Shenzhen Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingmin","family":"Wan","sequence":"additional","affiliation":[{"name":"Emergency and Disaster Medicine Center, the Seventh Affiliated Hospital, Sun Yat\u2010sen University  Shenzhen Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zijian","family":"Xie","sequence":"additional","affiliation":[{"name":"The Department of Cardiology Chenzhou No. 1 People's Hospital  Chenzhou Hunan Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tonghong","family":"Ding","sequence":"additional","affiliation":[{"name":"Emergency and Disaster Medicine Center, the Seventh Affiliated Hospital, Sun Yat\u2010sen University  Shenzhen Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9273-003X","authenticated-orcid":false,"given":"Zhifeng","family":"Mo","sequence":"additional","affiliation":[{"name":"Emergency and Disaster Medicine Center, the Seventh Affiliated Hospital, Sun Yat\u2010sen University  Shenzhen Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,21]]},"reference":[{"issue":"2","key":"e_1_2_10_2_1","first-page":"Cd003216","article-title":"Nutritional Interventions for Preventing and Treating Pressure Ulcers","volume":"2","author":"Langer G.","year":"2024","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"1","key":"e_1_2_10_3_1","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1111\/wrr.13130","article-title":"WHS Guidelines for the Treatment of Pressure Ulcers\u20102023 Update","volume":"32","author":"Gould L. J.","year":"2024","journal-title":"Wound Repair and Regeneration"},{"issue":"27","key":"e_1_2_10_4_1","doi-asserted-by":"crossref","first-page":"5630","DOI":"10.2174\/0109298673322825241018174928","article-title":"Pressure Ulcers and Nutrients: From Established Evidence to Gaps in Knowledge","volume":"32","author":"Kassym L.","year":"2025","journal-title":"Current Medicinal Chemistry"},{"issue":"1","key":"e_1_2_10_5_1","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1111\/wrr.12683","article-title":"The Humanistic and Economic Burden of Chronic Wounds: A Systematic Review","volume":"27","author":"Olsson M.","year":"2019","journal-title":"Wound Repair and Regeneration"},{"issue":"4","key":"e_1_2_10_6_1","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.jaad.2015.08.068","article-title":"Wound Healing and Treating Wounds: Differential Diagnosis and Evaluation of Chronic Wounds","volume":"74","author":"Morton L. M.","year":"2016","journal-title":"Journal of the American Academy of Dermatology"},{"issue":"1","key":"e_1_2_10_7_1","doi-asserted-by":"crossref","first-page":"64","DOI":"10.3390\/ijms22010064","article-title":"Role of microRNAs in Pressure Ulcer Immune Response, Pathogenesis, and Treatment","volume":"22","author":"Niemiec S. M.","year":"2020","journal-title":"International Journal of Molecular Sciences"},{"issue":"4","key":"e_1_2_10_8_1","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/j.jaad.2018.12.068","article-title":"Pressure Ulcers: Prevention and Management","volume":"81","author":"Mervis J. S.","year":"2019","journal-title":"Journal of the American Academy of Dermatology"},{"key":"e_1_2_10_9_1","doi-asserted-by":"crossref","first-page":"104891","DOI":"10.1016\/j.yexmp.2024.104891","article-title":"Decreased Proteasome Function Increases Oxidative Stress in the Early Stage of Pressure Ulcer Development","volume":"137","author":"Murata E.","year":"2024","journal-title":"Experimental and Molecular Pathology"},{"issue":"2","key":"e_1_2_10_10_1","doi-asserted-by":"crossref","first-page":"025025","DOI":"10.1088\/1758-5090\/ad2d2e","article-title":"Antibacterial, ROS Scavenging and Angiogenesis Promoting \u03f5\u2010Polylysine\/Gelatin Based Hydrogel Containing CTLP to Regulate Macrophages for Pressure Ulcer Healing","volume":"16","author":"Lin P.","year":"2024","journal-title":"Biofabrication"},{"issue":"2","key":"e_1_2_10_11_1","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1111\/bjd.13954","article-title":"Cellular and Molecular Mechanisms of Repair in Acute and Chronic Wound Healing","volume":"173","author":"Martin P.","year":"2015","journal-title":"British Journal of Dermatology"},{"issue":"1","key":"e_1_2_10_12_1","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1152\/physrev.00067.2017","article-title":"Wound Healing: A Cellular Perspective","volume":"99","author":"Rodrigues M.","year":"2019","journal-title":"Physiological Reviews"},{"key":"e_1_2_10_13_1","doi-asserted-by":"crossref","first-page":"15343","DOI":"10.2147\/IJN.S557042","article-title":"Micro\/Nanorobots in Wound Healing: Bridging the Gap From Concept to Clinical Translation","volume":"20","author":"Liu Y.","year":"2025","journal-title":"International Journal of Nanomedicine"},{"issue":"20","key":"e_1_2_10_14_1","doi-asserted-by":"crossref","first-page":"e1907322","DOI":"10.1002\/smll.201907322","article-title":"Cerium Oxide Nanoparticles: Advances in Biodistribution, Toxicity, and Preclinical Exploration","volume":"16","author":"Casals E.","year":"2020","journal-title":"Small (Weinheim an der Bergstrasse, Germany)"},{"issue":"19","key":"e_1_2_10_15_1","doi-asserted-by":"crossref","DOI":"10.3390\/molecules25194559","article-title":"Cerium Oxide Nanoparticles (Nanoceria): Hopes in Soft Tissue Engineering","volume":"25","author":"Sadidi H.","year":"2020","journal-title":"Molecules"},{"key":"e_1_2_10_16_1","doi-asserted-by":"crossref","first-page":"4503","DOI":"10.2147\/DDDT.S327378","article-title":"Anti\u2010Inflammatory Effects of Curcumin in the Inflammatory Diseases: Status, Limitations and Countermeasures","volume":"15","author":"Peng Y.","year":"2021","journal-title":"Drug Design, Development and Therapy"},{"issue":"3","key":"e_1_2_10_17_1","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1007\/s10787-023-01136-w","article-title":"Curcumin and Chemokines: Mechanism of Action and Therapeutic Potential in Inflammatory Diseases","volume":"31","author":"Sadeghi M.","year":"2023","journal-title":"Inflammopharmacology"},{"issue":"1","key":"e_1_2_10_18_1","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1186\/s12974-019-1538-9","article-title":"Ciprofloxacin and Levofloxacin Attenuate Microglia Inflammatory Response via TLR4\/NF\u2010kB Pathway","volume":"16","author":"Zusso M.","year":"2019","journal-title":"Journal of Neuroinflammation"},{"issue":"4","key":"e_1_2_10_19_1","doi-asserted-by":"crossref","first-page":"2489","DOI":"10.1002\/med.21802","article-title":"Pharmaceuticals Targeting Signaling Pathways of Endometriosis as Potential New Medical Treatment: A Review","volume":"41","author":"Hung S. 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