{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:23:57Z","timestamp":1788870237046,"version":"build-2803163510"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2003,6,5]],"date-time":"2003-06-05T00:00:00Z","timestamp":1054771200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"EVO Foundation of Turku University Central Hospital"},{"name":"Finnish Technology Foundation"},{"name":"Turku University Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Biomed Mater Res"],"published-print":{"date-parts":[[2003,7,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Three synthetic bioactive materials were studied in an experimental model to compare their usability in a frontal sinus and a skull bone defect obliteration. Bioactive glass number 9 (BAG\n                    <jats:sup>1<\/jats:sup>\n                    ), bioactive glass number 13 (BAG\n                    <jats:sup>2<\/jats:sup>\n                    ), and hydroxyapatite (HA) granules were investigated. BAG\n                    <jats:sup>1<\/jats:sup>\n                    and HA granules have been previously tested clinically. The clinical usefulness of BAG\n                    <jats:sup>2<\/jats:sup>\n                    granules has not been tested. Upper bony walls of 45 Elco rabbits' frontal sinuses were drilled open from four separate holes with the use of a standard method. The skull bone defects and the sinuses in frontal bone were filled with BAG\n                    <jats:sup>1<\/jats:sup>\n                    or BAG\n                    <jats:sup>2<\/jats:sup>\n                    on one side, and with HA on the other side. Two parallel posterior defects were covered with a pedicled periosteum flap, and two anterior defects with a free flap. The resorption of materials, new bone, and fibrous\u2010tissue formation were observed with a histomorphometric method at 1, 3, and 6 months postoperatively. Scanning\u2010electron microscopy (SEM) and Fourier\u2010transform infrared spectroscopy (FTIR) were done at 6 months. In histomorphometry, the new bone formation increased with all the investigated materials throughout the study (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.001), but the results showed higher new bone formation in the defects filled with BAG\n                    <jats:sup>1<\/jats:sup>\n                    than in corresponding BAG\n                    <jats:sup>2<\/jats:sup>\n                    \u2010 or HA\u2010 filled defects. New bone formation and resorption of materials were faster in defects covered by pedicled than by free periosteum flaps (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.001). Intimate contact between the used materials and new bone was confirmed by SEM. FTIR analysis of bone produced by BAG\n                    <jats:sup>1<\/jats:sup>\n                    and BAG\n                    <jats:sup>2<\/jats:sup>\n                    was of the same type as natural frontal bone. BAG\n                    <jats:sup>2<\/jats:sup>\n                    can be manufactured in various shapes, and thus, could possibly be used in clinical conditions requiring a special anatomical implant shape. However, more research is needed regarding this property of BAG\n                    <jats:sup>2<\/jats:sup>\n                    . \u00a9 2003 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 66B: 364\u2013372, 2003\n                  <\/jats:p>","DOI":"10.1002\/jbm.b.10023","type":"journal-article","created":{"date-parts":[[2003,6,10]],"date-time":"2003-06-10T06:09:31Z","timestamp":1055225371000},"page":"364-372","source":"Crossref","is-referenced-by-count":36,"title":["Frontal sinus and skull bone defect obliteration with three synthetic bioactive materials. A comparative study"],"prefix":"10.1002","volume":"66B","author":[{"given":"Matti J.","family":"Peltola","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kalle M. J.","family":"Aitasalo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jouko T. K.","family":"Suonp\u00e4\u00e4","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antti","family":"Yli\u2010Urpo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pekka 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