{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T05:16:21Z","timestamp":1783746981525,"version":"3.55.0"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2004,4,6]],"date-time":"2004-04-06T00:00:00Z","timestamp":1081209600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Biomed Mater Res"],"published-print":{"date-parts":[[2004,7,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>An adverse tissue response was reported in patients implanted with porous coated implants containing a mineral oil contaminant. A comparative staining technique was developed in a rabbit and sheep model to identify the presence of a mineral oil contaminant on porous coated implants by examining the surrounding tissues and end organs. The hypothesis for the study was that mineral oil, a saturated lipid, could be distinguished from unsaturated lipids such as animal fats. Frozen rabbit and sheep tissues were stained with hematoxylin and eosin, oil\u2010red\u2010O, and bromide\u2010silver nitrate. Twenty\u2010eight positive control rabbits were injected with mineral oil and 12 negative control rabbits were injected with saline into the paravertebral muscle and synovial cavity of the knee joint. Comparative analysis of tissue was conducted after 1, 3, 5, and 12 weeks. Thermally cleaned porous coated implants were implanted for 6, 12, and 24 weeks into cancellous bone of the distal femur of sheep to allow for a weight\u2010bearing model. The comparative histological analysis of the positive control rabbit tissue allowed for detection of mineral oil in all tissues examined. Histological analysis of sheep tissue and saline\u2010injected rabbit tissue showed no evidence of mineral oil or adverse tissue response. \u00a9 2004 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 70B: 130\u2013138, 2004<\/jats:p>","DOI":"10.1002\/jbm.b.30019","type":"journal-article","created":{"date-parts":[[2004,4,6]],"date-time":"2004-04-06T15:02:50Z","timestamp":1081263770000},"page":"130-138","source":"Crossref","is-referenced-by-count":1,"title":["A comparative staining technique to detect mineral oil contaminants from orthopedic implants"],"prefix":"10.1002","volume":"70B","author":[{"given":"Bettina M.","family":"Willie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. William","family":"Watts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana G.","family":"Szakacs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roy D.","family":"Bloebaum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,4,6]]},"reference":[{"key":"e_1_2_6_2_2","unstructured":"Recalled Sulzer inter\u2010op shells. Available:www.sulzer\u2010hip\u2010replacement.com;2003"},{"key":"e_1_2_6_3_2","unstructured":"Centerpulse approves settlement with minimal number of opt outs. Available:www.hipimplantlaw.com;2003"},{"key":"e_1_2_6_4_2","unstructured":"Hip implant recipient files products liability lawsuit against Sulzer Medica for alleged defects with the Sulzer inter\u2010op acetabular shell. Available:www.hipimplantlaw.com;2003."},{"key":"e_1_2_6_5_2","unstructured":"Sulzer knee defects. Available: www.sulzerkneereplacementrecall.com;2003."},{"key":"e_1_2_6_6_2","unstructured":"Sulzer's faulty manufacturing. Available:www.hipimplantlaw.com;2003."},{"key":"e_1_2_6_7_2","first-page":"1346","article-title":"Extractable residue from recalled inter\u2010op acetabular shells","author":"Spiegelberg SH","year":"2003","journal-title":"Trans Orthop Res Soc"},{"key":"e_1_2_6_8_2","article-title":"Bone viability in clinically compromised human cancellous bone from patients undergoing revision hip arthroplasty","author":"Bloebaum RD","journal-title":"J Arthroplasty."},{"key":"e_1_2_6_9_2","first-page":"562","article-title":"Micromineralization analysis of tibial bone wafers retrieved from contaminated porous coated implants","author":"Koller K","year":"2003","journal-title":"Trans Soc Biomat"},{"key":"e_1_2_6_10_2","first-page":"229","article-title":"Examination of recalled inter\u2010op acetabular cups for cause of failure","author":"Campbell P","year":"2002","journal-title":"Trans Soc Biomat"},{"key":"e_1_2_6_11_2","first-page":"187","article-title":"Histopathology of tissues from inter\u2010op acetabular sockets","author":"Campbell P","year":"2002","journal-title":"Trans Orthop Res Soc"},{"key":"e_1_2_6_12_2","first-page":"175","volume-title":"Laboratory methods in histotechnology: Armed Forces Institute of Pathology","author":"Johnson FB","year":"1992"},{"key":"e_1_2_6_13_2","first-page":"47","volume-title":"50 diagnostic special stains for surgical pathology","author":"Haas E","year":"1980"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1177\/8.3.189"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1177\/10.1.83"},{"key":"e_1_2_6_16_2","first-page":"150","volume-title":"Manual of histologic staining methods of the Armed Forces Insititute of Pathology","author":"Luna LG","year":"1968"},{"key":"e_1_2_6_17_2","first-page":"276","article-title":"Validation of mechanical loading of a porous coated implant in the medial condyle of the sheep","author":"Bloebaum R","year":"2003","journal-title":"Trans Soc Biom"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-199705000-00029"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-199604000-00003"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2001.218.669"},{"key":"e_1_2_6_21_2","volume-title":"H&E, Gills II & Alcoholic Philoxine Eosin Internal standard operating procedure from the SLC UA Health Care System","author":"Gilson G","year":"1995"},{"key":"e_1_2_6_22_2","first-page":"53","volume-title":"Laboratory methods in histotechnology: Armed Forces Institute of Pathology","author":"Allen TC","year":"1992"},{"key":"e_1_2_6_23_2","first-page":"347","article-title":"A method of identifying mineral oil in tissue using a sheep and rabbit model","author":"Willie BM","year":"2003","journal-title":"Trans Soc Biomat"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1179\/his.1994.17.4.343"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.3109\/10520298709108030"},{"key":"e_1_2_6_26_2","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1097\/00003086-199106000-00013","article-title":"Retrieval analysis of a hydroxyapatite\u2010coated hip prosthesis","volume":"267","author":"Bloebaum RD","year":"1991","journal-title":"Clin Orthop"},{"key":"e_1_2_6_27_2","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1179\/his.1989.12.4.307","article-title":"Plastic slides in the preparation of implant and tissue for interface analysis","volume":"12","author":"Bloebaum RD","year":"1989","journal-title":"J Histotechnol"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1179\/his.1990.13.1.63"}],"container-title":["Journal of Biomedical Materials Research Part B: Applied Biomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjbm.b.30019","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbm.b.30019","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T22:22:01Z","timestamp":1697149321000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbm.b.30019"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,4,6]]},"references-count":27,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2004,7,15]]}},"alternative-id":["10.1002\/jbm.b.30019"],"URL":"https:\/\/doi.org\/10.1002\/jbm.b.30019","archive":["Portico"],"relation":{},"ISSN":["1552-4973","1552-4981"],"issn-type":[{"value":"1552-4973","type":"print"},{"value":"1552-4981","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,4,6]]}}}