{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T09:13:51Z","timestamp":1789895631726,"version":"4.0.1"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,7,13]],"date-time":"2005-07-13T00:00:00Z","timestamp":1121212800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Biomed Mater Res"],"published-print":{"date-parts":[[2005,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A novel bioabsorbable composite membrane of polyethylene oxide terephthalate and polybutylene terephthalate copolymer (Polyactive\u00ae 70\/30) combined with bioactive glass No. 13\u201093 was tested in the repair of experimental maxillary alveolar cleft defects. In this pilot study, the possible ability of the membrane to promote bone formation by guided tissue regeneration was investigated. Standard alveolar defects were made bilaterally in the maxilla of 12 growing rabbits and were filled with autogenous bone grafts. The test defect was covered with the composite membrane and the other defect was left uncovered to serve as a control. The follow\u2010up time was 10 weeks. Radiological, histological, and histomorphometric evaluations were performed. Radiologically, no statistically significant differences between test and control defects at 10 weeks were found. Histologically, the membrane enhanced osteogenic activity locally at the membrane\u2013bone interface. Swelling of the membrane was observed. Histomorphometrically, no significant promotion of bone formation by the membrane was observed. The composite membrane was found to be biocompatible and surgically easy to use, but its osteopromotive effect was limited in this experimental cleft model. Further studies are necessary to assess its suitability for reconstructive surgical applications. \u00a9 2005 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2005<\/jats:p>","DOI":"10.1002\/jbm.b.30218","type":"journal-article","created":{"date-parts":[[2005,7,13]],"date-time":"2005-07-13T20:47:18Z","timestamp":1121287638000},"page":"25-33","source":"Crossref","is-referenced-by-count":16,"title":["A novel bioabsorbable composite membrane of Polyactive\u00ae 70\/30 and bioactive glass number 13\u201093 in repair of experimental maxillary alveolar cleft defects"],"prefix":"10.1002","volume":"75B","author":[{"given":"K.","family":"Puumanen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Kellom\u00e4ki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Ritsil\u00e4","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"B\u00f6hling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"T\u00f6rm\u00e4l\u00e4","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Waris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Ashammakhi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,7,13]]},"reference":[{"key":"e_1_2_7_2_2","first-page":"639","article-title":"Treatment of peri\u2010implant defects with guided bone regeneration: a comparative clinical study with various membranes and bone grafts","volume":"13","author":"Lorenzoni M","year":"1998","journal-title":"Int J Oral Maxillofac Implants"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1997.68.6.582"},{"key":"e_1_2_7_4_2","first-page":"844","article-title":"Resorbable versus non\u2010resorbable membranes in combination with Bio\u2010Oss for guided bone regeneration","volume":"12","author":"Zitzmann N","year":"1997","journal-title":"Int J Oral Maxillofac Implants"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.3109\/02844319609062809"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008848509911"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(02)00145-X"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0266-4356(95)90003-9"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1010-5182(05)80438-X"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.1994.050203.x"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002380100229"},{"key":"e_1_2_7_12_2","first-page":"13","volume-title":"Bone\u2010bonding biomaterials","author":"van Blitterswijk CA","year":"1992"},{"key":"e_1_2_7_13_2","first-page":"297","volume-title":"The bone\u2013biomaterial interface","author":"van Blitterswijk CA","year":"1991"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4636(199603)30:3<341::AID-JBM8>3.0.CO;2-Q"},{"key":"e_1_2_7_15_2","first-page":"189","volume-title":"Bone\u2010bonding biomaterials","author":"Okumura M","year":"1992"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4636(199707)36:1<109::AID-JBM13>3.0.CO;2-D"},{"key":"e_1_2_7_17_2","unstructured":"BrinkM.Bioactive glasses with a large working range[dissertation]. 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