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Copolymers of 2\u2010hydroxyethyl methacrylate (HEMA) and methacrylic acid (MAA) based hydrogels containing 2, 4, and 6% of a crosslinking agent (CA) were studied as drug delivery systems. Cubane\u20101, 4\u2010dicarboxylic acid (CDA) was linked to two HEMA groups as CA. Radical copolymerizations of HEMA and MAA with the various ratios of CA were performed at 70\u00b0C. The compositions of the crosslinked three\u2010dimensional polymers were determined using Fourier transform infrared spectroscopy. Glass\u2010transition temperature of the network polymers was determined calorimetrically. The effect of copolymer composition on the swelling behavior and hydrolytic degradation was studied in simulated gastric fluid (pH 1) and simulated intestinal fluid (pH 7.4). The swelling and hydrolytic behavior of the copolymers was dependent on the content of MAA groups and caused a decrease in gel swelling in simulated gastric fluid or an increase in gel swelling in simulated intestinal fluid. The drug\u2010release profiles indicate that the amount of drug release depends on their degree of swelling and crosslinking. \u00a9 2005 Wiley Periodicals, Inc. 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