{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T18:13:48Z","timestamp":1761675228113},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,7,22]],"date-time":"2005-07-22T00:00:00Z","timestamp":1121990400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Biomed Mater Res"],"published-print":{"date-parts":[[2005,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Although the short\u2010term results of implants with synthetic hydroxyapatite (HA), a bioactive material, have been favorable, few reports have been published concerning medium\u2010term outcomes for this therapy. The authors recently analyzed data supplied by 37 medical facilities nationwide concerning the outcomes of synthetic HA implants [Bonfil\u00ae (BF); Mitsubishi Materials Corporation, Tokyo] in 138 patients followed up for at least 5 years after treatment. When the data were analyzed, the patients were divided into two groups: the disease site\u2010filling group (62 cases where bone defects created by disease were filled with synthetic HA) and the donor site\u2010filling group (76 cases where bone defects created by bone donation were filled with synthetic HA). In the disease site\u2010filling group, synthetic HA was used in combination with autologous bone or autogenous bone marrow donated from the same patient in 77% of cases. In the donor site\u2010filling group, only synthetic HA was used in most cases. The average follow\u2010up period after implantation was 7.9 years in the disease site\u2010filling group and 9.1 years in the donor site\u2010filling group. Therapy was rated radiographically as \u201cvery effective\u201d or \u201ceffective\u201d in 81% of patients in the disease site\u2010filling group and in 89% of patients in the donor site\u2010filling group. The therapy was not rated as \u201cineffective\u201d in any case from either group. These results suggest that synthetic HA may serve as a very useful substitute for cancellous bone if used carefully, with its initial strength taken into account. \u00a9 2005 Wiley Periodicals, Inc. 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