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They play a critical role especially in skin conditions with an increased rate of bacterial and fungal infections like atopic dermatitis and hyperhidrosis, and in diabetic patients and aged skin. The present study demonstrates the antifungal and antibacterial effects of SeaCell\u00ae Active in an <jats:italic>in vitro<\/jats:italic> test system against <jats:italic>Candida albicans<\/jats:italic> (DSM 11225), <jats:italic>Candida tropicalis<\/jats:italic> (ATCC 1169), and <jats:italic>Candida krusei<\/jats:italic> (ATCC 6258). Furthermore, the antibacterial activity of fibers with different amounts of SeaCell\u00ae Active fibers in a dose\u2010dependent manner against <jats:italic>Staphylococcus aureus<\/jats:italic> (ATCC 22923) and <jats:italic>Escherichia coli<\/jats:italic> (ATCC 35218) could be demonstrated. If this fiber seems to be suited for bioactive textiles in specific anatomical regions and skin conditions with a susceptibility for fungal and bacterial infections due to Candida species, namely <jats:italic>Staphylococcus aureus<\/jats:italic> and <jats:italic>Escherichia coli<\/jats:italic>, must be examined by means of further investigations, especially <jats:italic>in vivo<\/jats:italic> tests in human, considering allergic and toxic effects of the fiber. \u00a9 2005 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2006<\/jats:p>","DOI":"10.1002\/jbm.b.30413","type":"journal-article","created":{"date-parts":[[2005,10,21]],"date-time":"2005-10-21T16:46:44Z","timestamp":1129913204000},"page":"156-163","source":"Crossref","is-referenced-by-count":46,"title":["Antifungal and antibacterial properties of a silver\u2010loaded cellulosic fiber"],"prefix":"10.1002","volume":"77B","author":[{"given":"Uta\u2010Christina","family":"Hipler","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Elsner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joachim W.","family":"Fluhr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,10,21]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2000.tb05454.x"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/67.1.4"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.0022-202X.2003.00204.x"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2003.12365.x"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1159\/000072235"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2004.01925.x"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.138.11.1462"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(99)80066-7"},{"key":"e_1_2_6_10_2","first-page":"27","article-title":"Skin changes of aging: Pathological implications","volume":"45","author":"Fenske NA","year":"1990","journal-title":"Geriatrics"},{"key":"e_1_2_6_11_2","unstructured":"ZikeliS.SeaCell\u00ae Active\u2014A new cellulosic fiber with antimicrobial properties. 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