{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T10:33:18Z","timestamp":1790505198499,"version":"4.1.0"},"reference-count":46,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,4,23]],"date-time":"2007-04-23T00:00:00Z","timestamp":1177286400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Biomed Mater Res"],"published-print":{"date-parts":[[2007,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>During the last few years Strontium has been shown to have beneficial effects when incorporated at certain doses in bone by stimulating bone formation. It is believed that its presence locally at the interface between an implant and bone will enhance osteointegration and therefore, ensure the longevity of a joint prosthesis. In this study we explore the possibility of incorporating Sr into nano\u2010apatite coatings prepared by a solution\u2010derived process according to an established biomimetic methodology for coating titanium based implants. The way this element is incorporated in the apatite structure and its effects on the stereochemistry and morphology of the resulting apatite layers was investigated, as well as its effect in the mineralization kinetics. By using the present methodology it was possible to incorporate increasing amounts of Sr in the apatite layers. Sr was found to incorporate in the apatite layer through a substitution mechanism by replacing Ca in the apatite lattice. The presence of Sr in solution induced an inhibitory effect on mineralization, leading to a decrease in the thickness of the mineral layers. The obtained Sr\u2010substituted biomimetic coatings presented a bone\u2010like structure similar to the one found in the human bone and therefore, are expected to enhance bone formation and osteointegration. \u00a9 2007 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 2007<\/jats:p>","DOI":"10.1002\/jbm.b.30791","type":"journal-article","created":{"date-parts":[[2007,4,23]],"date-time":"2007-04-23T20:16:24Z","timestamp":1177359384000},"page":"258-265","source":"Crossref","is-referenced-by-count":86,"title":["Strontium\u2010substituted apatite coating grown on Ti6Al4V substrate through biomimetic synthesis"],"prefix":"10.1002","volume":"83B","author":[{"given":"A. L.","family":"Oliveira","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. L.","family":"Reis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,4,23]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/8756-3282(90)90086-E"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002230010055"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/8756-3282(96)00080-4"},{"key":"e_1_2_6_5_2","first-page":"S306","article-title":"The strontium salt\u2010S12911 inhibits the expression of carbonic\u2010anhydrase and the vitronectin receptor in chicken bone\u2010marrow cultures and bone\u2010resorption in mouse calvaria and isolated rat osteoclasts","volume":"7","author":"Su Y","year":"1992","journal-title":"J Bone Miner Res"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2005.05.005"},{"key":"e_1_2_6_7_2","first-page":"5","article-title":"Effect of low\u2010doses of stable strontium on bone metabolism in rats","volume":"11","author":"Marie PJ","year":"1985","journal-title":"Miner Electrolyte Metab"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0026-0495(86)90013-2"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S8756-3282(01)00484-7"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S8756-3282(01)00419-7"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650110915"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S8756-3282(96)00316-X"},{"key":"e_1_2_6_13_2","first-page":"703","article-title":"Effects of oral supplementation with stable strontium","volume":"125","author":"Skoryna SC","year":"1981","journal-title":"Can Med Assoc J"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1159\/000260673"},{"key":"e_1_2_6_15_2","first-page":"329","article-title":"The effect of strontium lactate in the treatment of osteoporosis","volume":"34","author":"Mccaslin FE","year":"1959","journal-title":"Proc Staff Meet Mayo Clin"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1517\/13543784.13.7.857"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1358\/dot.2003.39.2.799416"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa022436"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.060101"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-1774"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.820211203"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-199612000-00018"},{"key":"e_1_2_6_23_2","first-page":"147","article-title":"Chemical implant fixation using hydroxyl\u2010apatite coatings\u2014The development of a human total hip\u2010prosthesis for chemical fixation to bone using hydroxyl\u2010apatite coatings on titanium substrates","volume":"225","author":"Geesink RGT","year":"1987","journal-title":"Clin Orthop Relat Res"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4636(19980905)41:3<341::AID-JBM1>3.0.CO;2-C"},{"key":"e_1_2_6_25_2","first-page":"101","article-title":"Biomimetic coating of starch based polymeric foams produced by a calcium silicate based methodology","volume":"240","author":"Oliveira AL","year":"2003","journal-title":"Bioceramics"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008900428325"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/0142-9612(93)90186-6"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.820240607"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.10519"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1211\/0022357023312"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2004.03.004"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.30310"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.289.5484.1508"},{"key":"e_1_2_6_34_2","unstructured":"LiP; DePuy Orthopaedics Inc. assignee. Bioactive ceramic coating and method. USA Pat (2000) 6 569 489."},{"key":"e_1_2_6_35_2","unstructured":"LiP; DePuy Products Inc. assignee. Strontium\u2010substituted apatite coating. 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