{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T18:18:07Z","timestamp":1761675487367},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2007,3,23]],"date-time":"2007-03-23T00:00:00Z","timestamp":1174608000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Biomed Mater Res"],"published-print":{"date-parts":[[2007,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Bisphosphonates are promising in the treatment of periprosthetic osteolysis induced by particulate wear debris. The <jats:italic>in vivo<\/jats:italic> effects of pamidronate with different doses and durations of administration on bone\u2010titanium attachment in the presence of endotoxin\u2010coated polyethylene particles were examined in a rat model in this study. Titanium pins and endotoxin\u2010coated polyethylene particles were introduced into rat femoral canals followed by intraperitoneal injection of pamidronate every other day. The treatment varied in the dose from 0 to 40 \u03bcg\/kg and the duration of either 10 days or 6 weeks. Bilateral femurs were harvested after 6 weeks and examined by bone densitometer and MicroCT scan. Pamidronate increased the bone density of the left, unoperated femurs in a dose and duration dependent manner. Bone\u2010titanium attachment significantly increased in all treatment groups compared to the control group. When pamidronate was administered for 10 days, the increase of bone\u2010titanium attachment was significantly dose\u2010dependent. However, when pamidronate was given for 6 weeks at 4 \u03bcg\/kg, the bone\u2010titanium attachment was significantly (<jats:italic>p<\/jats:italic> &lt; 0.001) lower compared to the 10 day treatment of the same dose, although it was significantly higher than controls. Our results suggest that pamidronate effectively increase bone\u2010titanium attachment even in the presence of endotoxin\u2010coated polyethylene particles. However, long\u2010term administration may reduce its efficacy. \u00a9 2007 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2007<\/jats:p>","DOI":"10.1002\/jbm.b.30803","type":"journal-article","created":{"date-parts":[[2007,3,23]],"date-time":"2007-03-23T16:32:17Z","timestamp":1174667537000},"page":"354-358","source":"Crossref","is-referenced-by-count":6,"title":["Administration of pamidronate alters bone\u2010titanium attachment in the presence of endotoxin\u2010coated polyethylene particles"],"prefix":"10.1002","volume":"83B","author":[{"given":"Zhiqing","family":"Xing","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen A.","family":"Hasty","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard A.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,3,23]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.blo.0000149821.72760.39"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-200112000-00008"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.30512"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/jor.20038"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.30150"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0736-0266(01)00179-6"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.blo.0000149998.88218.05"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4636(199605)31:1<91::AID-JBM11>3.0.CO;2-P"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S8756-3282(99)00116-7"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.orthres.2003.12.015"},{"key":"e_1_2_6_12_2","first-page":"66","article-title":"Effects of bisphosphonate on bone reaction after placement of titanium implants in tibiae of variectomized rats","volume":"18","author":"Tokugawa Y","year":"2003","journal-title":"Int J Oral Maxillofac Implants"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-200202000-00010"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2004.06.010"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-199711000-00005"},{"key":"e_1_2_6_16_2","unstructured":"RubashH DorrL JacobsJ MaloneyW SaagK malbecqW LeungA.Does alendronate inhibit the progression of periprosthetic osteolysis?In: Proceedings of 50th Annual Meeting of the Orthopaedic Research Society San Francisco CA March 7\u201310 2004. 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