{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:13:52Z","timestamp":1790208832649,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,12,20]],"date-time":"2007-12-20T00:00:00Z","timestamp":1198108800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Biomed Mater Res"],"published-print":{"date-parts":[[2008,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Embolization of blood vessels may result in a variety of side effects which can include pain and inflammation. The objective of this study was to assess the release and effect of ibuprofen (IBU) from Bead Block\u2122 microspheres (BB) loaded with IBU (IBU\u2010BB) on the foreign body inflammatory reaction in a sheep uterine artery model. Both uterine arteries of 12 hormonally cycled ewes were embolized with 0.5 mL of 500\u2013700 \u03bcm BB (<jats:italic>n<\/jats:italic> = 6) or IBU\u2010BB (<jats:italic>n<\/jats:italic> = 6). Animals were sacrificed at 1 week (1W) or 3 weeks (3W) (<jats:italic>n<\/jats:italic> = 3 each group). The gross examination of the organs was performed and distribution of the beads in the tissue was assessed. Inflammation was estimated histologically by quantitative and semiquantitative classification of inflammatory cells on HES and MGG stains and use of videoanalysis after immunohistolabeling with CD\u2010antibodies to a variety of inflammatory cells. At 1W, a significant decrease of inflammatory response was observed for IBU\u2010BB relative to BB in terms of number of lymphocytes and of immunohistochemical staining for CD172a, MHC\u2010II, CD3, and CD4. At 3W, the inflammatory response for IBU\u2010BB was similar to that for BB at 1W in terms of cell populations and moderate intensity. There was no or low amounts of staining for CD8 and CD45RA and none for CD21 in all four groups. Immunohistochemical detection of IBU showed that some drug was still present in the beads at 1W but none was detectable at 3W suggesting it had all eluted. These results signify that the inflammatory response is dampened by the action of IBU eluted from the beads and that IBU\u2010BB can delay postembolization inflammatory reaction. \u00a9 2007 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2008<\/jats:p>","DOI":"10.1002\/jbm.b.30988","type":"journal-article","created":{"date-parts":[[2007,12,20]],"date-time":"2007-12-20T19:02:21Z","timestamp":1198177341000},"page":"63-73","source":"Crossref","is-referenced-by-count":22,"title":["Anti\u2010inflammatory effect of ibuprofen\u2010loaded embolization beads in sheep uterus"],"prefix":"10.1002","volume":"86B","author":[{"given":"Michel","family":"Wassef","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Pierre","family":"Pelage","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elodie","family":"Velzenberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Namur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Schwartz\u2010Cornil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel R.","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew L.","family":"Lewis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Laurent","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,12,20]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(95)92282-2"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.RVI.0000052287.26939.b0"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(02)04538-7"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.RVI.0000136982.42548.5D"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.RVI.0000136983.45640.E4"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.RVI.0000136982.42548.5D"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.gco.0000183945.76602.6b"},{"key":"e_1_2_5_9_2","first-page":"4","article-title":"Time course of pain after uterine artery embolization for fibroid disease","volume":"7","author":"Worthington\u2010Kirsch RL","year":"2002","journal-title":"Medscape Womens Health"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000165828.68787.a9"},{"key":"e_1_2_5_11_2","first-page":"73","volume-title":"Uterine Artery Embolization and Gynecologic Embolotherapy","author":"Bonn J","year":"2005"},{"key":"e_1_2_5_12_2","first-page":"217","volume-title":"In Pharmacology","author":"Rang HP","year":"2003"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2006.08.008"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004424-200112000-00007"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2242010847"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0404223"},{"key":"e_1_2_5_17_2","unstructured":"LaurentA WassefM PelageJP VelzenbergerE NamurJ Schwartz\u2010CornilI MartalJ MerlandJJ.Quantification of inflammatory reaction towards Embosphere and Contour SE microspheres after embolization in uterine sheep Cirse Barcelona Spain September 24\u201329;2004. p144."},{"key":"e_1_2_5_18_2","unstructured":"LaurentA WassefM PelageJP VelzenbergerE Schwartz\u2010CornilI MerlandJJ.Inflammatory reaction developed around Trisacryl\u2010Gelatin and Polyvinyl\u2010Alcohol microspheres in sheep SIR New Orleans USA;2005."},{"key":"e_1_2_5_19_2","unstructured":"NamurJ WassefM PelageJP LaurentA.Arterial location of three sizes of Embosphere\u00ae and Bead Block\u00ae in sheep uterus model. Cardiovascular and Interventional Society of Europe CIRSE Nice France September 10\u201314 2005. p156."},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.rli.0000188027.34400.f3"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/jps.2600820215"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1208\/pt020424"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(00)00099-5"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.54.3.201"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.82B5.9946"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1594.1996.tb04414.x"},{"key":"e_1_2_5_27_2","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1128\/cdli.3.2.156-161.1996","article-title":"Phenotype of lymphocytes associated with the inflammatory reaction to silicone gel breast implants","volume":"3","author":"Katzin WE","year":"1996","journal-title":"Clin Diagn Lab Immunol"},{"key":"e_1_2_5_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-4636(2001)58:1<88::AID-JBM130>3.0.CO;2-7"},{"key":"e_1_2_5_29_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2006.00474.x"},{"key":"e_1_2_5_30_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.173.11.6955"},{"issue":"3","key":"e_1_2_5_31_2","first-page":"S563","article-title":"A comparison of oral ibuprofen and intravenous indomethacin for closure of patent ductus arteriosus in preterm infants","volume":"86","author":"Chotigeat U","year":"2003","journal-title":"J Med Assoc Thai"},{"key":"e_1_2_5_32_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.112.5.e354"},{"key":"e_1_2_5_33_2","doi-asserted-by":"publisher","DOI":"10.1136\/fn.76.3.F179"},{"key":"e_1_2_5_34_2","first-page":"107","article-title":"Ibuprofen toxicity. A review of adverse reactions and overdose","volume":"12","author":"Halpern SM","year":"1993","journal-title":"Adverse Drug React Toxicol Rev"}],"container-title":["Journal of Biomedical Materials Research Part B: Applied Biomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjbm.b.30988","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbm.b.30988","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T09:58:12Z","timestamp":1696845492000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbm.b.30988"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,12,20]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,7]]}},"alternative-id":["10.1002\/jbm.b.30988"],"URL":"https:\/\/doi.org\/10.1002\/jbm.b.30988","archive":["Portico"],"relation":{},"ISSN":["1552-4973","1552-4981"],"issn-type":[{"value":"1552-4973","type":"print"},{"value":"1552-4981","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,12,20]]}}}