{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T08:15:48Z","timestamp":1782548148496,"version":"3.54.5"},"reference-count":48,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,12,27]],"date-time":"2007-12-27T00:00:00Z","timestamp":1198713600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Biomed Mater Res"],"published-print":{"date-parts":[[2008,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Our goal was to evaluate bone neoformation promoted by a bovine xenograft composite (XC) compared with autogenous graft for maxillary sinus augmentation in a rabbit model. The left maxillary sinus of 18 male rabbits was filled with 200 mg of cortical and cancellous autogenous bone and the right sinus was filled with 200 mg of a composite comprised organic and inorganic bovine matrices, pool of bBMPs and collagen. Postoperative implant intervals of 2, 4, and 8 weeks were analyzed. Differences in the bone optical density among the groups and experimental periods were evaluated by computed tomography analysis. The tissue response was evaluated by histomorphometric analysis of the newly formed bone, connective tissue and\/or granulation tissue, residual material, and bone marrow. The tomographic analyses showed a maximum optical density in the 4\u2010week period for both groups. Histologically, an inflammatory infiltrate was observed at 2 weeks in the XC group but exclusively around the organic particles of the biomaterial. Regarding to the amount of newly formed bone, no statistical differences (<jats:italic>p<\/jats:italic> &gt; 0.05) were observed among the two treatments throughout the implant intervals. However, by the end of the 8 weeks, the quantity of bone marrow was two times greater (<jats:italic>p<\/jats:italic> &lt; 0.05) in the control group than in the XC group. In conclusion, the xenograft composite promotes formation of new bone in a similar fashion to autogenous bone and could therefore be considered a biomaterial with potential applications as a bone substitute in maxillary sinus floor augmentation. \u00a9 2007 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2008<\/jats:p>","DOI":"10.1002\/jbm.b.31005","type":"journal-article","created":{"date-parts":[[2007,12,27]],"date-time":"2007-12-27T19:16:46Z","timestamp":1198783006000},"page":"188-196","source":"Crossref","is-referenced-by-count":10,"title":["Comparative histomorphometric and tomographic analysis of maxillary sinus floor augmentation in rabbits using autografts and xenografts"],"prefix":"10.1002","volume":"86B","author":[{"given":"Cristina Miguel","family":"Sicca","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro Vin\u00edcius","family":"Corotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00edlvia Helena Pereira Vergili","family":"Sgarbosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tania Mary","family":"Cestari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo Gusm\u00e3o Para\u00edso","family":"Cavalcanti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo Martins","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rumio","family":"Taga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Mauro","family":"Granjeiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,12,27]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"23","article-title":"Maxillary sinus augmentation with the xenograft Bio\u2010Oss and autogenous intraoral bone for qualitative improvement of the implant site: A histologic and histomorphometric clinical study in humans","volume":"16","author":"Yildirim M","year":"2001","journal-title":"Int J Oral Maxillofac Implants"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.2001.120511.x"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.2002.130511.x"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bdj.4810987"},{"key":"e_1_2_6_6_2","first-page":"175","article-title":"A review of survival rates for implants placed in grafted maxillary sinuses using meta\u2010analysis","volume":"13","author":"Tong DC","year":"1998","journal-title":"Int J Oral Maxillofac Implants"},{"key":"e_1_2_6_7_2","first-page":"53","article-title":"Histologic findings in sinus augmentation with autogenous bone chips versus a bovine bone substitute","volume":"18","author":"Schlegel KA","year":"2003","journal-title":"Int J Oral Maxillofac Implants"},{"key":"e_1_2_6_8_2","first-page":"556","article-title":"Maxillary sinus grafting with anorganic bovine bone: A clinical report of long\u2010term results","volume":"18","author":"Valentini P","year":"2003","journal-title":"Int J Oral Maxillofac Implants"},{"key":"e_1_2_6_9_2","first-page":"199","article-title":"Histomorphometric analysis of natural bone mineral for maxillary sinus augmentation","volume":"19","author":"John H","year":"2004","journal-title":"Int J Oral Maxillofac Implants"},{"key":"e_1_2_6_10_2","first-page":"222","article-title":"Sinus floor augmentation with bovine hydroxyapatite mixed with fibrin glue and later placement of non submerged implants: A retrospective study in 50 patients","volume":"19","author":"Hallman M","year":"2004","journal-title":"Int J Oral Maxillofac Implants"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.150.3698.893"},{"key":"e_1_2_6_12_2","first-page":"13","article-title":"Reparo de defeito \u00f3sseo perene em cr\u00e2nio de cobaia pela aplica\u00e7\u00e3o de osseobond","volume":"3","author":"Taga R","year":"1997","journal-title":"Rev Bras Implant"},{"key":"e_1_2_6_13_2","first-page":"87","volume-title":"Osseous Reconstruction of the Maxilla and the Mandible\u2014Surgical Techniques using Titanium Mesh and Bone Mineral","author":"Peetz M","year":"1997"},{"key":"e_1_2_6_14_2","first-page":"85","article-title":"Efeito da temperatura da desproteiniza\u00e7\u00e3o no preparo de osso cortical bovino microgranular. 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