{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T12:44:16Z","timestamp":1774615456275,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,12,27]],"date-time":"2007-12-27T00:00:00Z","timestamp":1198713600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Biomed Mater Res"],"published-print":{"date-parts":[[2008,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose:<\/jats:title><jats:p>The objective of this study was to clinically evaluate the use of OSTEON\u00ae as a sinus graft material and to measure the effect of healing at 4 and 6 months after surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods:<\/jats:title><jats:p>After sinus graft using OSTEON\u00ae in 17 patients, bone specimens were collected from lateral sinus using 2.0\u2010mm trephine bur at the time of 4 or 6 months after surgery. Histology of the bone specimens was prepared and the percentage of newly formed bone fraction, lamellar bone\/woven bone ratio (LB\/WB), and newly formed bone\/graft material ratio (NB\/GM) were measured to indicate the suitability of the materials and the successful healing of the graft.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>The morphology of OSTEON\u00ae was observed to be interconnected, with 77% porosity and a pore size of 300\u2013500 \u03bcm. After implantation, the mean percentage of newly formed bone fraction after 4 months and 6 months surgery was 40.6 and 51.9%, respectively. Statistical analysis indicated no significant difference (<jats:italic>p<\/jats:italic> = 0.135) in the newly formed bone fraction between the two postoperative periods. The mean LB\/WB ratio after 4 months and 6 months surgery was 0.14 and 0.45, respectively, with significant difference observed between the two postoperative periods (<jats:italic>p<\/jats:italic> = 0.027). Additionally, the mean NB\/GM ratio after 4 months and 6 months surgery was 1.95 and 7.72, respectively, with significant difference observed between the two postoperative periods (<jats:italic>p<\/jats:italic> = 0.046).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p>It was concluded that OSTEON\u00ae is suitable for use in sinus graft application since desirable time\u2010dependent healing was demonstrated. \u00a9 2007 Wiley Periodicals, Inc. 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