{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T11:03:18Z","timestamp":1792062198633,"version":"4.4.0"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2008,3,21]],"date-time":"2008-03-21T00:00:00Z","timestamp":1206057600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Biomed Mater Res"],"published-print":{"date-parts":[[2008,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Polyethylene wear particles are one of the most important factors affecting the results of total hip arthroplasty (THA). To reduce wear generation and to achieve better long\u2010term results of THA, highly crosslinked polyethylene (HXPE) has recently been introduced and come into wide use. Thus far, however, there have been no reports on <jats:italic>in vivo<\/jats:italic> analysis of HXPE wear particles. We isolated HXPE wear particles from periprosthetic tissue of a failed THA and analyzed using scanning electron microscope. The number of particles was 5.33 \u00d7 10<jats:sup>7<\/jats:sup> g<jats:sup>\u22121<\/jats:sup>. Particle size (equivalent circle diameter) was 0.66 \u00b1 0.40 \u03bcm (mean \u00b1 standard error). Aspect ratio and roundness were 1.37 \u00b1 0.26 and 1.44 \u00b1 0.67, respectively. All the particles were round shaped, and \u201cfibrils\u201d or \u201cshreds\u201d were not detected. Thus far, this was the first report on <jats:italic>in vivo<\/jats:italic> wear particle analysis of HXPE. HXPE generated less, smaller, and rounder particles, compared with the corresponding reported values for particles generated from conventional polyethylene. These characteristics might affect macrophage response, osteolysis, and long\u2010term results of THA with HXPE. \u00a9 2008 Wiley Periodicals, Inc. 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