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Previously, we quantified the delivery of both polystyrene and polyethylene particles over 2\u2010 and 4\u2010week time periods using osmotic pumps and collection tubes. In the present study, we used explanted mice femora in organ culture and showed that continuous intramedullary delivery of submicron\u2010sized polymer particles using osmotic pumps is feasible. Furthermore, infusion of 2.60 \u00d7 10<jats:sup>11<\/jats:sup> particles per mL (intermediate concentration) of ultrahigh molecular weight polyethylene (UHMWPE) for 2 weeks and 8.06 \u00d7 10<jats:sup>11<\/jats:sup> particles per mL (high concentration) UHMWPE for 4 weeks both yielded significantly higher scores for bone loss when compared with controls in which only mouse serum was infused. \u00a9 2008 Wiley Periodicals, Inc. 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