{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T17:17:47Z","timestamp":1760548667983},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2008,5,27]],"date-time":"2008-05-27T00:00:00Z","timestamp":1211846400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Biomed Mater Res"],"published-print":{"date-parts":[[2008,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cemented total hip replacements generally fail after 10\u201320 years, often due to implant loosening from bone resorption. Bisphosphonates such as zoledronic acid (ZA) and pamidronate (PAM) are potent inhibitors of bone resorption. The local delivery of bisphosphonates via acrylic bone cement could decrease osteolysis and prolong implant lifespan. Conflicting studies suggest that bisphosphonate loading may or may not reduce the mechanical properties of acrylic bone cement. We assayed acrylic bone cement laden with ZA or PAM at different concentrations and diluent volumes. Four\u2010point bend testing and compressive testing indicated that high volumes of diluent (with or without bisphosphonate) significantly reduced bending modulus and compressive strength. Radiography and electron microscopy indicated that high diluent volumes generated abnormal acrylic bone cement structure. After 6 weeks of incubation in saline, only 0.9% w\/w of the total bisphosphonate incorporated in acrylic bone cement eluted <jats:italic>in vitro<\/jats:italic>, indicating a slow elution rate. <jats:italic>In vivo<\/jats:italic> testing was performed using a rat model. Cement cylinders were inserted into incisions in rat distal femora and ZA delivered locally (via elution from acrylic bone cement) or systemically (via injection). At 4 weeks postoperatively, dual energy X\u2010ray absorptiometry demonstrated no significant increase in local bone mineral density (BMD) adjacent to ZA\u2010laden implants. In contrast, systemic ZA delivery (0.1 mg\/kg) led to a large (48.6%) and significant increase in BMD. Thus, systemic delivery appears more effective than local delivery. \u00a9 2008 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2008<\/jats:p>","DOI":"10.1002\/jbm.b.31130","type":"journal-article","created":{"date-parts":[[2008,5,28]],"date-time":"2008-05-28T01:55:22Z","timestamp":1211939722000},"page":"482-491","source":"Crossref","is-referenced-by-count":13,"title":["Bisphosphonate\u2010laden acrylic bone cement: Mechanical properties, elution performance, and <i>in vivo<\/i> activity"],"prefix":"10.1002","volume":"87B","author":[{"given":"Nicole Y. 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ISO5833:2002(E): Annex E: determination of compressive strength of polymerized cement. International Standard Organisation;2002. pp19\u201322."},{"key":"e_1_2_7_22_2","unstructured":"International Standard Organisation (ISO).Implants for surgery\u2014Acrylic resin cements. ISO5833:2002(E): Annex F: determination of bending modulus and bending strength of polymerized cement. 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