{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T16:11:22Z","timestamp":1774109482464,"version":"3.50.1"},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2008,12,23]],"date-time":"2008-12-23T00:00:00Z","timestamp":1229990400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Biomed Mater Res"],"published-print":{"date-parts":[[2009,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>In vivo<\/jats:italic> oxidation of gamma air\u2010sterilized ultrahigh\u2010molecular\u2010weight polyethylene (UHMWPE) has been observed when joint replacement hip and knee components are explanted during revision surgery. The purpose of the present study was to extend a previously published accelerated aging protocol for gamma\u2010sterilized UHMWPE. Unsterilized and gamma\u2010sterilized GUR 1150 resin samples were aged in phosphate\u2010buffered saline (PBS) at 40 or 50\u00b0C for up to 52 weeks. Under these conditions, slower changes in oxidation index (OI) occurred than those previously observed by aging at 60\u00b0C. Reduction of aging temperature below 60\u00b0C also changed the kinetics of oxidation such that the aldehyde peak (1732 cm<jats:sup>\u22121<\/jats:sup>) present at higher temperature was eliminated making the ketone\/carboxylic acid region (1713\u20131718 cm<jats:sup>\u22121<\/jats:sup>) the primary region contributing to the calculation of the OIs for each group. The oxidation profiles obtained after 52 weeks at 40 and 50\u00b0C were consistent with retrievals that have undergone low oxidation, associated with maximum OI values of less than 1. Aging at 50\u00b0C represents a compromise between the slower oxidation rate of <jats:italic>in vivo<\/jats:italic> temperatures and the nonphysiological kinetics of elevated temperatures in an aqueous environment. However, even at 50\u00b0C over a year of <jats:italic>in vitro<\/jats:italic> aqueous aging will be necessary to reproduce the oxidation levels observed in long\u2010term implanted acetabular retrievals. \u00a9 2008 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2009<\/jats:p>","DOI":"10.1002\/jbm.b.31294","type":"journal-article","created":{"date-parts":[[2008,12,23]],"date-time":"2008-12-23T14:18:09Z","timestamp":1230041889000},"page":"368-372","source":"Crossref","is-referenced-by-count":16,"title":["Accelerated aqueous aging simulation of <i>in vivo<\/i> oxidation for gamma\u2010sterilized UHMWPE"],"prefix":"10.1002","volume":"90B","author":[{"given":"Steven M.","family":"Kurtz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan L.","family":"Siskey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Dumbleton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,12,23]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2005.07.015"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.D.02111"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.blo.0000246547.18187.0b"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2005.07.019"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(99)00053-8"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.30454"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1520\/STP1445-EB"},{"key":"e_1_2_6_9_2","first-page":"175","article-title":"In vitro chemical and mechanical degradation of UHMWPE: One year results","volume":"19","author":"Rimnac CM","year":"1994","journal-title":"Trans 40th ORS"},{"key":"e_1_2_6_10_2","first-page":"221","article-title":"Ionizing irradiation for sterilization and modification of high molecular weight polyethylenes","volume":"10","author":"Streicher RM","year":"1988","journal-title":"Plast Rubber Proc Appl"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0141-3910(97)00265-6"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2005.10.002"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.30514"},{"key":"e_1_2_6_14_2","volume-title":"Standard Guide for Accelerated Aging of Ultra High Molecular Weight Polyethylene","author":"ASTM F 2003\u201002","year":"2002"},{"key":"e_1_2_6_15_2","volume-title":"Standard Guide for Evaluating the Extent of Oxidation in Ultra High Molecular Weight Polyethylene Fabricated From Intended for Surgical Implants","author":"ASTM F 2102\u201006","year":"2002"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(00)00333-1"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.blo.0000238856.61862.7d"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2005.04.026"}],"container-title":["Journal of Biomedical Materials Research Part B: Applied Biomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjbm.b.31294","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbm.b.31294","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T12:51:15Z","timestamp":1696855875000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbm.b.31294"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,12,23]]},"references-count":17,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2009,7]]}},"alternative-id":["10.1002\/jbm.b.31294"],"URL":"https:\/\/doi.org\/10.1002\/jbm.b.31294","archive":["Portico"],"relation":{},"ISSN":["1552-4973","1552-4981"],"issn-type":[{"value":"1552-4973","type":"print"},{"value":"1552-4981","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,12,23]]}}}