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For implant devices in contact with blood, the underlying premise is that proteins and other components in blood do not significantly change the corrosion susceptibility. This study examined the corrosion behavior of nitinol in bovine serum and PBS containing amino acids (cysteine, glutamine, and tryptophan). Tests were performed on mechanically polished (MP) and black oxide (BO) nitinol wire using cyclic potentiodynamic polarization and electrochemical impedance spectroscopy. They showed that the susceptibility to pitting corrosion of MP nitinol in PBS can be influenced by the presence of amino acids, depending on the type of amino acid. However, the pitting susceptibility of MP and BO nitinol did not differ significantly (based on a <jats:italic>t<\/jats:italic>\u2010test, with <jats:italic>p<\/jats:italic> &lt; 0.05 being statistically significant) between serum and PBS, suggesting that the combination of proteins and amino acids in serum had little effect. The impedance spectra showed near\u2010capacitive behavior in serum and in PBS alone and with amino acids, and the data could be fitted by a parallel resistance\u2013capacitance (as a constant phase element) circuit associated with the passive oxide film. The capacitance indicated that serum proteins were adsorbed on nitinol but that little, if any, adsorption of the three amino acids under study occurred at the corrosion potential. There did not appear to be a correlation between breakdown and the adsorption of organic compounds in serum. \u00a9 2010 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2010.<\/jats:p>","DOI":"10.1002\/jbm.b.31647","type":"journal-article","created":{"date-parts":[[2010,6,2]],"date-time":"2010-06-02T03:36:22Z","timestamp":1275449782000},"page":"287-295","source":"Crossref","is-referenced-by-count":18,"title":["Corrosion behavior of nitinol in blood serum and PBS containing amino acids"],"prefix":"10.1002","volume":"94B","author":[{"given":"Bruce G.","family":"Pound","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,6]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.820130206"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1177\/00220345800590100601"},{"key":"e_1_2_7_4_2","volume-title":"The Effect of a Novel Biopolymer on the Corrosion of 316L Stainless Steel and Ti6Al4V Alloys in a Physiologically Relevant Electrolyte","author":"Hansen DC","year":"2007"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0142-9612(88)90119-6"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.10099"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-4636(200011)52:2<323::AID-JBM11>3.0.CO;2-Z"},{"key":"e_1_2_7_8_2","unstructured":"Standard test method for conducting cyclic potentiodynamic polarization measurements to determine the corrosion susceptibility of small implant devices ASTM Standard F 2129\u201306 ASTM International West Conshohocken Pennsylvania 2006."},{"key":"e_1_2_7_9_2","first-page":"21","volume-title":"Corrosion","author":"Shreir LL","year":"1994"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.32075"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI104186"},{"key":"e_1_2_7_12_2","first-page":"59","volume-title":"Absorption and Utilization of Amino Acids","author":"Umezawa C","year":"1989"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-3233(08)60506-9"},{"key":"e_1_2_7_14_2","first-page":"1179","volume-title":"Uhlig's corrosion handbook","author":"Silverman DC","year":"2000"},{"key":"e_1_2_7_15_2","first-page":"299","volume-title":"Tutorial on Cyclic Potentiodynamic Polarization Technique","author":"Silverman DC","year":"1998"},{"key":"e_1_2_7_16_2","first-page":"68","volume-title":"ASM Handbook","author":"Scully JR","year":"2003"},{"key":"e_1_2_7_17_2","first-page":"236","volume-title":"ASM Handbook","author":"Frankel GS","year":"2003"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.31616"},{"key":"e_1_2_7_19_2","unstructured":"PopaMV VasilescuE DrobP Mirza\u2010RoscaI LopezAS AnghelM VasilescuC. 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