{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T06:29:50Z","timestamp":1791872990383,"version":"4.3.4"},"reference-count":36,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2010,6,24]],"date-time":"2010-06-24T00:00:00Z","timestamp":1277337600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Biomed Mater Res"],"published-print":{"date-parts":[[2010,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>P\u201015 is a synthetic 15\u2010amino acid residue identical to the cell binding domain of type I collagen. P\u201015 can be adsorbed onto anorganic bovine bone mineral (ABM) and will enhance cell attachment and subsequent cell activation. Although ABM\/P\u201015 has been studied as a bone graft substitute in the oral cavity, its use in orthopedic models has been limited. Thus, this study investigated the efficacy of ABM\/P\u201015 treatment in a rabbit model of long bone cancellous healing. Defects were created in the distal femurs and proximal medial tibiae of rabbits and were filled with either ABMP\/P\u201015 suspended in hydrogel, ABM alone suspended in hydrogel, hydrogel carrier alone, or no graft material. Rabbits were sacrificed at 1, 2, 4, or 8 weeks postsurgery, and the femurs and tibiae were harvested. Histomorphometric analyses indicated that defects treated with ABM\/P\u201015 had significantly larger areas of new bone formation than the other three treatments at 2 and 8 weeks postsurgery. ABM\/P\u201015 treated defects also had significantly more bone growth than defects left empty or filled with ABM alone at 4 weeks postsurgery. Furthermore, histological examination did not reveal acute inflammatory infiltrate cells in any of the treatment conditions. These results are consistent with the findings of ABM\/P\u201015 use in human oral\u2010maxillofacial studies and in large animal spine fusion models. \u00a9 2010 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2010.<\/jats:p>","DOI":"10.1002\/jbm.b.31676","type":"journal-article","created":{"date-parts":[[2010,6,24]],"date-time":"2010-06-24T18:22:12Z","timestamp":1277403732000},"page":"463-468","source":"Crossref","is-referenced-by-count":24,"title":["Small peptide (P\u201015) bone substitute efficacy in a rabbit cancellous bone model"],"prefix":"10.1002","volume":"94B","author":[{"given":"Emily M.","family":"Lindley","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando A.","family":"Guerra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack","family":"T. 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