{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T18:23:13Z","timestamp":1761675793016},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2010,10,21]],"date-time":"2010-10-21T00:00:00Z","timestamp":1287619200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Biomed Mater Res"],"published-print":{"date-parts":[[2011,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In this work, we investigated the efficacy of PECE\u2010hydrogel in preventing postsurgical peritoneal adhesions in the rat uterine horn model. Standardized surgical traumas were applied to the peritoneum of the abdominal wall and the uterine horns. PECE hydrogel was applied to the two wound surfaces. Animals were euthanized at different times after surgery, and the gross necropsy findings were documented. Adhesion formation was assessed according to adhesion extent and adhesion severity, and the hydrogel degradation and healing of peritoneal wounds were observed. The remesothelialization was dynamically observed by scanning electron microscope. The results showed that none of the animals in the hydrogel\u2010treated group (<jats:italic>n<\/jats:italic> = 12) developed adhesion. In contrast, all untreated animals (<jats:italic>n<\/jats:italic> = 12) had adhesions that could only be separated by sharp dissection (<jats:italic>p<\/jats:italic> &lt; 0.001). The hydrogel could adhere to the peritoneal wounds and gradually disappear from the wounds within 7\u20139 days and transformed into viscous fluid being completely absorbed within 12 days. The injured parietal and visceral peritoneum was remesothelialized in about 7 and 9 days, respectively. This work confirmed that PECE hydrogel holds promise as a novel absorbable biomaterial for the reduction of postoperative adhesions after laparotomy. \u00a9 2010 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2011.<\/jats:p>","DOI":"10.1002\/jbm.b.31739","type":"journal-article","created":{"date-parts":[[2010,10,21]],"date-time":"2010-10-21T13:05:23Z","timestamp":1287666323000},"page":"57-66","source":"Crossref","is-referenced-by-count":12,"title":["Prevention of abdominal adhesion formation by thermosensitive PECE\u2010hydrogel in a rat uterine horn model"],"prefix":"10.1002","volume":"96B","author":[{"given":"Bing","family":"Yang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang","family":"Yang Gong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi","family":"Yong Qian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xia","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zheng","family":"Yu Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheng","family":"Tao Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao","family":"Rong Qi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Quan Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,10,21]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)57470-6"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(99)00464-1"},{"key":"e_1_2_6_4_2","first-page":"60","article-title":"Intestinal obstruction from adhesions\u2014How big is the problem?","volume":"72","author":"Menzies D","year":"1990","journal-title":"Ann R Coll Surg Engl"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/7.6.567"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)56507-8"},{"key":"e_1_2_6_7_2","first-page":"297","article-title":"Prevention of postoperative abdominal adhesions by a sodium hyaluronate\u2010based bioresorbable membrane: A prospective, randomized, double\u2010blind multicenter study","volume":"183","author":"Becker JM","year":"1996","journal-title":"J Am Coll Surg"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/12.9.1935"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1159\/000050149"},{"key":"e_1_2_6_10_2","first-page":"291","article-title":"Adhesive small bowel obstruction: Epidemiology, biology and prevention","volume":"50","author":"Attard JA","year":"2007","journal-title":"Can J Surg"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(98)00057-0"},{"key":"e_1_2_6_12_2","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1016\/S0015-0282(16)60721-5","article-title":"Prevention of postsurgical adhesions by INTERCEED(TC7), an absorbable adhesion barrier: A prospective randomized multicenter clinical study. INTERCEED (TC7) Adhesion Barrier Study Group","volume":"51","year":"1989","journal-title":"Fertil Steril"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)54802-X"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2006.05.023"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.820280710"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1177\/030006059902700503"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2004.09.038"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2006.04.043"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000251519.49405.55"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2008.08.027"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.31370"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(97)00573-6"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1843.2002.00404.x"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1080\/08860220701741619"},{"key":"e_1_2_6_25_2","first-page":"52","article-title":"Recent clinical developments in pathophysiology, epidemiology, diagnosis and treatment of intra\u2010abdominal adhesions","author":"Dijkstra FR","year":"2000","journal-title":"Scand J Gastroenterol Suppl"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.4141"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)90061-2"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1042\/bst0300126"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1080\/110241599750007810"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(02)04569-7"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(98)00496-8"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1159\/000010034"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711510309"},{"key":"e_1_2_6_34_2","first-page":"24","article-title":"Cytokine regulation of mesothelial cell proliferation in vitro and in vivo","volume":"72","author":"Mutsaers SE","year":"1997","journal-title":"Eur J Cell Biol"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9896(200001)190:1<86::AID-PATH493>3.0.CO;2-G"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.115.7.1383"}],"container-title":["Journal of Biomedical Materials Research Part B: Applied Biomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjbm.b.31739","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbm.b.31739","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T03:52:47Z","timestamp":1696909967000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbm.b.31739"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,10,21]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,1]]}},"alternative-id":["10.1002\/jbm.b.31739"],"URL":"https:\/\/doi.org\/10.1002\/jbm.b.31739","archive":["Portico"],"relation":{},"ISSN":["1552-4973","1552-4981"],"issn-type":[{"value":"1552-4973","type":"print"},{"value":"1552-4981","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,10,21]]}}}