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In our study, we compared a resorbable electrochemically deposited calcium phosphate coating (Bonit<jats:sup>\u00ae<\/jats:sup>) to a thin (40 \u03bcm) plasma\u2010sprayed hydroxyapatite (HA) coating, applied on grit\u2010blasted screw\u2010shaped Ti\u20106Al\u20104V implants in the cortical region of rabbit tibia, implanted for 6, 12, and 52 weeks. The removal torque results demonstrated stronger bone\u2010to\u2010implant fixation for the HA than Bonit\u2010coated screws at 6 and 12 weeks. After 52 weeks, the fixation was in favor of the Bonit\u2010coated screws, but the difference was statistically insignificant. Coat flaking and delamination of the HA with multinucleated giant cell activity and bone resorption observed histologically seemed to preclude any significant increase in fixation comparing the HA implants at 6 versus 12 weeks and 12 versus 52 weeks. The Bonit\u2010coated implants exhibited increasing fixation from 6 to 12 weeks and from 12 to 52 weeks, and the coat was resorbed within 6 weeks, with minimal activity of multinucleated giant cells or bone resorption. A different fixation pattern was observed for the two coatings with a sharper but time limited increase in fixation for the HA\u2010coated screws, and a slower but more steadily increasing fixation pattern for the Bonit\u2010coated screws. The side effects were more serious for the HA coating and limiting the expected increase in fixation with time. \u00a9 2011 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2011.<\/jats:p>","DOI":"10.1002\/jbm.b.31866","type":"journal-article","created":{"date-parts":[[2011,6,6]],"date-time":"2011-06-06T18:25:06Z","timestamp":1307384706000},"page":"14-20","source":"Crossref","is-referenced-by-count":33,"title":["Different patterns of bone fixation with hydroxyapatite and resorbable CaP coatings in the rabbit tibia at 6, 12, and 52 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