{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T00:49:44Z","timestamp":1789174184900,"version":"build-2803163510"},"reference-count":37,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,6,16]],"date-time":"2012-06-16T00:00:00Z","timestamp":1339804800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Biomed Mater Res"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Adhesions, particularly in the abdominal and pelvic cavities, represent a significant clinical problem. Among other complications, they are considered the most common cause of intestinal obstructions in the Western world. The purpose of this study was to evaluate two commercially available hemostats for their ability to prevent adhesion formation in an abdominal wound model. The hemostats, a microfibrillar collagen\u2010based composite and microporous polysaccharide spheres were used in a rabbit abdominal model. In the model the cecum was abraded and a peritoneal defect was created on the abdominal sidewall. The test materials were applied over the defects. Clinical and histological results were compared with control (no application of any hemostat at the defect site) on postoperative day 14.<\/jats:p><jats:p>The results showed a significant reduction in the incidence, extent and severity of adhesions for both surgical hemostat materials compared with control. The microfibrillar collagen\u2010based composite showed a total absence of adhesions and a high level of reperitonealization.<\/jats:p><jats:p>This preclinical study suggests that the use of surgical hemostats may help to reduce or eliminate adhesions and may promote reperitonealization. \u00a9 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 100B: 1621\u20131626, 2012.<\/jats:p>","DOI":"10.1002\/jbm.b.32730","type":"journal-article","created":{"date-parts":[[2012,6,17]],"date-time":"2012-06-17T21:58:34Z","timestamp":1339970314000},"page":"1621-1626","source":"Crossref","is-referenced-by-count":6,"title":["Adhesion prevention in an intraperitoneal wound model: Performance of two resorbable hemostats in a controlled study in rabbits"],"prefix":"10.1002","volume":"100B","author":[{"given":"Michel H. E.","family":"Hermans","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marissa","family":"Darmoc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,6,16]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"817","volume-title":"Surgery: Scientific Principles and Practice","author":"Soybel D","year":"1997"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1318.2007.01358.x"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1023\/B:DDAS.0000034571.30602.36"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2000.tb11083.x"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(73)80123-0"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.137.7.822"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4636(19970305)34:3<291::AID-JBM3>3.0.CO;2-F"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(99)80125-1"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e318217e99c"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00298566"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001703-199306000-00006"},{"key":"e_1_2_6_13_2","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1177\/000313489906500521","article-title":"The effects of minidose heparin and low molecular weight heparin on peritonitis in the rat","volume":"65","author":"Vela AR","year":"1999","journal-title":"Am Surg"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1159\/000134919"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0756.2009.01077.x"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1080\/11024159950189780"},{"key":"e_1_2_6_17_2","first-page":"115","article-title":"[Peritoneal adhesions: Pathophysiology]","volume":"29","author":"Fabiano G","year":"2008","journal-title":"Il Giornale di chirurgia"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1177\/039139880703000611"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.33083"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/micr.1920080406"},{"key":"e_1_2_6_21_2","first-page":"497","article-title":"The cause and prevention of postoperative intraperitoneal adhesions","volume":"133","author":"Ellis H","year":"1971","journal-title":"Surg Gynecol Obstetrics"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-005-0706-4"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.smj.0000182133.98781.19"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2482-7-14"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00595-007-3590-9"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)54432-X"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2007.01.108"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2006.04.043"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2004.12.012"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.10081"},{"key":"e_1_2_6_31_2","volume-title":"Collagen (3): Biotechnology","author":"Wallace D","year":"1988"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4612-1194-5_1"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1082389"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2008.08.008"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800820103"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2004.046276"},{"key":"e_1_2_6_37_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00586-003-0645-5"},{"key":"e_1_2_6_38_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.10509"}],"container-title":["Journal of Biomedical Materials Research Part B: Applied Biomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjbm.b.32730","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbm.b.32730","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T04:26:02Z","timestamp":1696911962000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbm.b.32730"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6,16]]},"references-count":37,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2012,8]]}},"alternative-id":["10.1002\/jbm.b.32730"],"URL":"https:\/\/doi.org\/10.1002\/jbm.b.32730","archive":["Portico"],"relation":{},"ISSN":["1552-4973","1552-4981"],"issn-type":[{"value":"1552-4973","type":"print"},{"value":"1552-4981","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,6,16]]}}}