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Perforations are repaired using a variety of techniques, but are limited by morbidity, unsatisfactory closure rates, or minimal regeneration of the connective tissue. A more effective, minimally\u2010invasive therapy is necessary to enhance the perforation closure rate. Current research utilizing decellularized or alignate materials moderately enhance closure but the native TM architecture is not restored. Poly(glycerol sebacate) (PGS) is a biocompatible elastomer which supports cell migration and enzymatically degrades in contact with vascularized tissue. PGS spool\u2010shaped plugs were manufactured using a novel process. Using minimally invasive procedures, these elastomeric plugs were inserted into chronic chinchilla TM perforations. As previously reported, effective perforation closure occurred as both flange surfaces were covered by confluent cell layers; &gt;90% of perforations were closed at 6\u2010week postimplantation. This unique <jats:italic>in vivo<\/jats:italic> environment has little vascularized tissue. Consequently, PGS degradation was minimal over 16\u2010week implantation, hindering regeneration of the TM fibrous connective tissue. PGS degradation must be enhanced to promote complete TM regeneration. \u00a9 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2012.<\/jats:p>","DOI":"10.1002\/jbm.b.32761","type":"journal-article","created":{"date-parts":[[2012,7,23]],"date-time":"2012-07-23T11:41:14Z","timestamp":1343043674000},"page":"1943-1954","source":"Crossref","is-referenced-by-count":18,"title":["Behavior of poly(glycerol sebacate) plugs in chronic tympanic membrane perforations"],"prefix":"10.1002","volume":"100B","author":[{"given":"C. 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