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We evaluated the regeneration of three calcium phosphate synthetic block bone grafts in rabbit calvarial noncritical size defects. Four 8\u2010mm\u2010diameter defects were created in each rabbit (<jats:italic>N<\/jats:italic> = 10). Three defects, hydroxyapatite (HA), beta\u2010tricalcium phosphate (\u03b2\u2010TCP), and biphasic calcium phosphate (BCP), were randomly filled with one of three fabricated synthetic block bone graft materials. The fourth defect was filled with blood clots. Specimens were harvested at 4 and 8 weeks postsurgery. Histological and histometrical findings indicated that all three calcium phosphate block bone graft materials were able to maintain space significantly better than the control group at both 4 and 8 weeks. In the BCP group, the amount of newly formed bone was increased more than for the other groups. Additionally, \u03b2\u2010TCP showed a large resorption of graft materials after 4 weeks postsurgery, while there were only small resorption for HA and BCP. \u00a9 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2012.<\/jats:p>","DOI":"10.1002\/jbm.b.32768","type":"journal-article","created":{"date-parts":[[2012,8,3]],"date-time":"2012-08-03T17:38:40Z","timestamp":1344015520000},"page":"2044-2052","source":"Crossref","is-referenced-by-count":35,"title":["Comparative evaluation of three calcium phosphate synthetic block bone graft materials for bone regeneration in rabbit 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