{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T17:18:41Z","timestamp":1791134321222,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2012,8,9]],"date-time":"2012-08-09T00:00:00Z","timestamp":1344470400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Biomed Mater Res"],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Periodontitis is caused by periodontopathic bacteria and antibacterial agents are placed in a periodontal pocket with the intention of enhancing the local effect. To maximize the therapeutic effects while reducing the adverse effects, tinidazole was delivered by <jats:italic>in situ<\/jats:italic> forming system. One approach for reducing burst release rate was to testify <jats:italic>in situ<\/jats:italic> forming effect. The effect of 0%\u201310% (w\/w) polyethylene glycol 400 and 3% (w\/w) glycerol on the tinidazole release from a poly(<jats:sc>DL<\/jats:sc>\u2010lactide) (PLA) injectable implant was evaluated. The results showed that the <jats:italic>in vitro<\/jats:italic> initial burst release rate was decreased in the presence of poly(ethyleneglycol) PEG 400 and glycerol. A formulation containing 30% (w\/w) PLA (<jats:italic>M<\/jats:italic><jats:sub>w<\/jats:sub> 7300) dissolved in 62% (w\/w) <jats:italic>N<\/jats:italic>\u2010methyl\u20102\u2010pyrrolidone, 5% (w\/w) PEG 400, and 3%(w\/w) glycerol with 5% (w\/w) tinidazole was shown to be optimum. Twelve adult beagle dogs were used in the periodontitis model. The treatment group I, II, and positive control group was administrated with gel containing 5%(w\/w) tinidazole, 2.5%(w\/w) tinidazole, and periocline, respectively. Dog studies revealed that periocline and the developed formulation could significantly decrease symptoms of periodontitis, and they were better than gel containing 2.5% (w\/w) tinidazole. The developed formulation could sustain the release of tinidazole for local delivery over 7 days. These findings suggested that the developed formulation was a viable alternative to conventional drug to cure periodontitis. \u00a9 2012 Wiley Periodicals, Inc. 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