{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T11:48:23Z","timestamp":1763466503052},"reference-count":28,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2012,9,21]],"date-time":"2012-09-21T00:00:00Z","timestamp":1348185600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Biomed Mater Res"],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Current stent system efficacy for the treatment of coronary artery disease is hampered by in\u2010stent restenosis (ISR) rates of up to 20% in certain high\u2010risk settings and by the risk of stent thrombosis, which is characterized by a high mortality rate. In theory, biodegradable vascular devices exhibit crucial advantages. Most absorbable implant materials are based on poly\u2010<jats:sc>L<\/jats:sc>\u2010lactic acid (PLLA) owing to its mechanical properties; however, PLLA might induce an inflammatory reaction in the vessel wall. Evaluation of biodegradable implant efficacy includes a long\u2010term examination of tissue response; therefore, a simple<jats:italic>in vivo<\/jats:italic>tool for thorough biocompatibility and biodegradation evaluation would facilitate future stent system development. Rats have been used for the study of<jats:italic>in vivo<\/jats:italic>degradation processes, and stent implantation into the abdominal aorta of rats is a proven model for stent evaluation. Here, we report the transformation of the porcine double\u2010stent animal model into the high\u2010throughput rat abdominal aorta model. As genetic manipulation of rats was introduced recently, this novel method presents a powerful tool for future<jats:italic>in vivo<\/jats:italic>biodegradable candidate stent biocompatibility and biodegradation characterization in a reliable simple model of coronary ISR. \u00a9 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2012.<\/jats:p>","DOI":"10.1002\/jbm.b.32810","type":"journal-article","created":{"date-parts":[[2012,9,21]],"date-time":"2012-09-21T06:13:07Z","timestamp":1348207987000},"page":"2023-2028","source":"Crossref","is-referenced-by-count":2,"title":["Introduction of a high\u2010throughput double\u2010stent animal model for the evaluation of biodegradable vascular stents"],"prefix":"10.1002","volume":"100B","author":[{"given":"Mauricio","family":"Borinski","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Flege","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabian","family":"Schreiber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole","family":"Krott","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Gries","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisa","family":"Liehn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R\u00fcdiger","family":"Blindt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikolaus","family":"Marx","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felix","family":"Vogt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,9,21]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"19","article-title":"Developments in coronary artery stenting: Primum non nocere","volume":"53","author":"Simsek C","year":"2011","journal-title":"Panminerva Med"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2005.07.049"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.03.042"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.004762"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1177\/0885328206065125"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.971606"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.102.4.399"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.970772"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ehj.2004.06.010"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1583\/04-1466.1"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1159\/000080891"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.820280314"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2010.06.057"},{"key":"e_1_2_5_15_2","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1515\/aut-2010-100304","article-title":"Improving the mechanical properties of braided shape memory polymer stents by heat setting","volume":"0","author":"Schreiber F","year":"2010","journal-title":"Autex Res J"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.275.5302.964"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/jps.20957"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2010.14"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00270-009-9572-0"},{"key":"e_1_2_5_20_2","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1160\/TH04-02-0124","article-title":"Platelet deposition on stainless steel, spiral, and braided polylactide stents. 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