{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T07:11:13Z","timestamp":1696921873757},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,9,21]],"date-time":"2012-09-21T00:00:00Z","timestamp":1348185600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Biomed Mater Res"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hydroxyethyl starch (HES) solutions, widely used plasma substitutes, reportedly attenuate capillary leakage via physical plugging of capillary defects. We investigated how 2% HES solutions of different molecular weights (HES<jats:sub>70<\/jats:sub>: 70 kDa, HES<jats:sub>130<\/jats:sub>: 130 kDa, HES<jats:sub>200<\/jats:sub>: 200 kDa, and HES<jats:sub>670<\/jats:sub>: 670 kDa) affect dye release from polyacrylamide gels (PAGs) as a model of endothelial glycocalyx. We assessed dye release from 4% PAG with varying concentrations of albumin [0, 1, 2, 4, and 8% (w\/v)] by measuring the change in dye absorbance (\u0394Abs) at 5 h for each HES solution. For PAG containing no albumin, \u0394Abs for HES<jats:sub>130<\/jats:sub> was 30% lower than that for HES<jats:sub>70<\/jats:sub> and HES<jats:sub>200<\/jats:sub>, and 50% lower than that for HES<jats:sub>670<\/jats:sub>. At concentrations of 1\u20138% albumin, \u0394Abs at 5 h with HES<jats:sub>70<\/jats:sub>, HES<jats:sub>130<\/jats:sub>, and HES<jats:sub>200<\/jats:sub> solutions were almost half that with the HES<jats:sub>670<\/jats:sub> solution, but no significant differences were noted in \u0394Abs at 5 h among HES<jats:sub>70<\/jats:sub>, HES<jats:sub>130<\/jats:sub>, and HES<jats:sub>200<\/jats:sub> solutions. The inhibition of dye release by HES<jats:sub>670<\/jats:sub> is likely due to the hindering effect of HES molecules partitioned into gel pores. However, a unique property of HES<jats:sub>130<\/jats:sub>, including the heavy hydroxyethylation at the C<jats:sub>2<\/jats:sub> position, may promote specific interactions with PAG and thereby inhibit solute release. \u00a9 2012 Wiley Periodicals, Inc. 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