{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:35:52Z","timestamp":1787067352242,"version":"build-2736575974"},"reference-count":38,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,10,24]],"date-time":"2013-10-24T00:00:00Z","timestamp":1382572800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Biomed Mater Res"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Treatments of osteomyelitis lag behind bacterial resistance to antibiotics. We tested different\u2010sized calcium sulfate beads and their ability to elute multiple antibiotics\n                    <jats:italic>in vitro<\/jats:italic>\n                    as a possible method to improve the therapeutic delivery in patients. Two sizes of calcium sulfate beads (4.8 and 3.0 mm diameter) that contained vancomycin, tobramycin, or both were dissolved in phosphate\u2010buffered saline, and the rate of dissolution by weight and antibiotic elution by the disc diffusion assay and high\u2010pressure liquid chromatography were measured. The 4.8 mm beads showed significantly higher dissolution rates relative to the 3.0 mm beads (2.3 mg\/day vs. 1.3 mg\/day). While the vancomycin\u2010loaded 4.8 mm beads eluted for a longer time relative to the 3.0 mm beads (20 days vs. 10 days), the smaller beads had threefold higher elution for the first 2 days, before dropping to near zero elution by day 4. The presence of tobramycin extended the elution of the vancomycin to day 40, which closely matches the recommended 6 weeks to treat orthopedic staphylococcus infections. These data suggest that size and content of the bead are variables that could affect their clinical success, and both could be exploited to tailor treatments of specific infections and injuries. \u00a9 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 102B: 667\u2013673, 2014.\n                  <\/jats:p>","DOI":"10.1002\/jbm.b.33045","type":"journal-article","created":{"date-parts":[[2013,10,24]],"date-time":"2013-10-24T05:53:46Z","timestamp":1382594026000},"page":"667-673","source":"Crossref","is-referenced-by-count":54,"title":["Size and composition of synthetic calcium sulfate beads influence dissolution and elution rates\n                    <i>in vitro<\/i>"],"prefix":"10.1002","volume":"102","author":[{"given":"Randy","family":"Roberts","sequence":"first","affiliation":[{"name":"Department of Orthopaedics The Ohio State University Wexner Medical Center Columbus Ohio 43210"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen J.","family":"McConoughey","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics The Ohio State University Wexner Medical Center Columbus Ohio 43210"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason 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