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Despite hernia prevalence, repairs can still fail due to postoperative complications, such as chronic pain and decreased mobility. This study compared repair capacities and characterized the foreign body response elicited by a number of hernia repair grafts to deduce their bulk inflammatory properties while also concluding the point in their fabrication when these are inferred. Materials derived from human dermis (Alloderm<jats:sup>\u00ae<\/jats:sup>), porcine dermis (Permacol\u2122, patch A, patch D and Strattice<jats:sup>\u00ae<\/jats:sup>), porcine small\u2010intestinal submucosa (Surgisis\u2122) and a synthetic (multifilament Surgipro\u2122) were implanted into a rat full\u2010thickness abdominal wall excision model, incubated for up to 2 years and characterized histopathologically. Surgisis\u2122 resorbed the fastest of the materials tested (1\u20133 months) resulting in a mechanically stable parietal peritoneum. Decellularization using sodium dodecyl sulfate (patch A) stimulated a large early inflammatory response which ultimately may have contributed to increased resorption of porcine dermal matrix however the remaining materials typically persisted throughout the 2\u2010year incubation. Cross\u2010linking porcine dermis using 1,6\u2010hexamethylene disocyanate (vs. an identical noncross\u2010linked counterpart) showed no difference in cell recruitment or material integration over 2 years. Typically Strattice<jats:sup>\u00ae<\/jats:sup> and Alloderm<jats:sup>\u00ae<\/jats:sup> recruited larger early populations of cells than Permacol\u2122; however, over extended periods of time <jats:italic>in vivo<\/jats:italic> this response normalized. \u00a9 2013 Wiley Periodicals, Inc. 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