{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T21:35:04Z","timestamp":1791408904358,"version":"4.3.3"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,10,21]],"date-time":"2013-10-21T00:00:00Z","timestamp":1382313600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Biomed Mater Res"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Current methods for closure of congenital diaphragmatic hernia using patches are unsatisfactory, and novel collagen\u2010based scaffolds have been developed, and successfully applied in a rat model. However, for translation to the human situation constructs must be evaluated in larger animal models. We developed collagen scaffolds enforced with Vicryl, loaded either with or without the muscle stimulatory growth factor insulin\u2010like growth factor 1 (IGF1). We describe our steps to a surgical method to implant these scaffolds into a diaphragmatic defect in 1.5\u20133 week old lambs, and evaluate the scaffolds 6 months after implantation. Omentum was attached to the scaffold. At sacrifice, eventration of the implantation site was observed in all animals with a thin layer of tissue separating the abdomen from the thorax. Histologically, no scaffold remnants could be observed. Fatty tissue surrounded by fibrous tissue was seen, resembling encapsulated omentum, with collagen\u2010rich tissue present between this tissue and the original diaphragmatic muscle. Outcomes were not different for scaffolds with or without IGF1. In conclusion, the scaffolds integrated well into the surrounding tissue, but slower degrading materials are needed to prevent eventrations. \u00a9 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 102B: 756\u2013763, 2014.<\/jats:p>","DOI":"10.1002\/jbm.b.33056","type":"journal-article","created":{"date-parts":[[2013,10,21]],"date-time":"2013-10-21T07:50:39Z","timestamp":1382341839000},"page":"756-763","source":"Crossref","is-referenced-by-count":13,"title":["Collagen\u2010Vicryl scaffolds for reconstruction of the diaphragm in a large animal model"],"prefix":"10.1002","volume":"102","author":[{"given":"Katrien M.","family":"Brouwer","sequence":"first","affiliation":[{"name":"Department of Biochemistry 280 NCMLS, Radboud university medical centre P.O. Box 9101, 6500 HB Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Willeke F.","family":"Daamen","sequence":"additional","affiliation":[{"name":"Department of Biochemistry 280 NCMLS, Radboud university medical centre P.O. Box 9101, 6500 HB Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henk R.","family":"Hoogenkamp","sequence":"additional","affiliation":[{"name":"Department of Biochemistry 280 NCMLS, Radboud university medical centre P.O. Box 9101, 6500 HB Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul J.","family":"Geutjes","sequence":"additional","affiliation":[{"name":"Department of Urology 267 NCMLS, Radboud university medical centre 6500 HB Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivo","family":"de Blaauw","sequence":"additional","affiliation":[{"name":"Department of Surgery 801 Radboud university medical centre P.O. 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