{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T17:49:26Z","timestamp":1777052966354,"version":"3.51.4"},"reference-count":41,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,1,17]],"date-time":"2014-01-17T00:00:00Z","timestamp":1389916800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Biomed Mater Res"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>It has been accepted that bone damage and subsequent resorption occurs in cases of adverse interfacial bone strain. Fractured implants represents an important opportunity for evaluating the bone response to overstrain. The objective of the study was to analyze the bone morphology and morphometry around retrieved fractured implants in humans. Five fractured implants retrieved after 22.4 (\u00b1 2.8) years were used in the present study. The investigation was conducted in a transmitted brightfield and circularly polarized light Microscope. The parameters considered were the total bone area, total bone remodeling area, bone\u2010remodeling rate (BRR), and bone transverse collagen fibers orientation (CFO).<\/jats:p><\/jats:sec><jats:sec><jats:title>Findings<\/jats:title><jats:p>For grouped samples, the BRR was 51.9% (\u00b1 10) while the transverse CFO was 13.0% (\u00b1 9.7). The interthread BRR was 58.1% (\u00b1 4.0) for level 1 and 40.4% (\u00b1 12.8) for level 2 with a significant decrease in BRR (<jats:italic>p<\/jats:italic>\u2009=\u20090.019) as a function of depth along the implant length.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Both bone level and bone quality attains stability to a certain level with respect to implant neck fracture following physiologic interaction between mechanical and biological inputs. The BRR significantly decrease as function of threads depth. \u00a9 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 102B: 1342\u20131352, 2014.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jbm.b.33109","type":"journal-article","created":{"date-parts":[[2014,1,17]],"date-time":"2014-01-17T05:40:48Z","timestamp":1389937248000},"page":"1342-1352","source":"Crossref","is-referenced-by-count":10,"title":["Human bone reactions around implants with adverse interfacial bone strain over 20 years"],"prefix":"10.1002","volume":"102","author":[{"given":"Tonino","family":"Traini","sequence":"first","affiliation":[{"name":"Department of Medical Oral and Biotechnological Sciences University of Chieti\u2010Pescara  Italy"},{"name":"Department of Dentistry San Raffaele Hospital Vita\u2010Salute University Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo","family":"Mangano","sequence":"additional","affiliation":[{"name":"Department of Surgical and Morphological Sciences Insubria University Varese Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vittoria","family":"Perrotti","sequence":"additional","affiliation":[{"name":"Department of Medical Oral and Biotechnological Sciences University of Chieti\u2010Pescara  Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio","family":"Caputi","sequence":"additional","affiliation":[{"name":"Department of Medical Oral and Biotechnological Sciences University of Chieti\u2010Pescara  Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulo","family":"Coelho","sequence":"additional","affiliation":[{"name":"Departments of Biomaterials and Biomimetics and Periodontology and Implant Dentistry New York University College of Dentistry New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriano","family":"Piattelli","sequence":"additional","affiliation":[{"name":"Department of Medical Oral and Biotechnological Sciences University of Chieti\u2010Pescara  Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanna","family":"Iezzi","sequence":"additional","affiliation":[{"name":"Department of Medical Oral and Biotechnological Sciences University of Chieti\u2010Pescara  Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,1,17]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"12","article-title":"Analysis of factors affecting crestal bone loss around the implants","volume":"3","author":"Park J\u2010H","year":"2009","journal-title":"J Kor Dent Sci"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2002.73.3.322"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1708-8208.2009.00200.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.1996.070208.x"},{"key":"e_1_2_6_6_1","first-page":"425","article-title":"The influence of controlled occlusal overload on peri\u2010implant tissue. 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