{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T15:48:20Z","timestamp":1791301700768,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,6,12]],"date-time":"2014-06-12T00:00:00Z","timestamp":1402531200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Biomed Mater Res"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Urinary tract infections constitute a large proportion of nosocomial infections, and the urinary catheter is the most important predisposing factor. Encrustation induced by urease\u2010producing uropathogens like <jats:italic>Proteus mirabilis<\/jats:italic> causes further complications. In the present work, a strategy for controllable and sustained release of silver over several weeks has been developed for combating bacterial infection and encrustation in urinary devices. Silver nanoparticles (AgNPs) were first immobilized on polydopamine (PDA) pre\u2010treated silicone catheter surface and this was followed by another PDA coating. The number of AgNP\u2010PDA bilayers could be manipulated to control the amount of silver loaded and its subsequent release. Poly(sulfobetaine methacrylate\u2010<jats:italic>co<\/jats:italic>\u2010acrylamide) was then grafted to provide an antifouling outer layer, and to ensure free diffusion of Ag from the surface. The micron\u2010scale combination of an antifouling coating with AgNP\u2010PDA bilayers reduced colonization of the urinary catheter by uropathogens by approximately two orders of magnitude. With one and two AgNP\u2010PDA bilayers, the coated catheter could resist encrustation for 12 and 45 days, respectively, compared with approximately 6 days with the Dover\u2122 silver\u2010coated catheter. Such anti\u2010infective and anti\u2010encrustation catheters can potentially have a large impact on reducing patient morbidity and healthcare expenditure. \u00a9 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 103B: 519\u2013528, 2015.<\/jats:p>","DOI":"10.1002\/jbm.b.33230","type":"journal-article","created":{"date-parts":[[2014,6,12]],"date-time":"2014-06-12T10:19:49Z","timestamp":1402568389000},"page":"519-528","source":"Crossref","is-referenced-by-count":106,"title":["Antifouling coating with controllable and sustained silver release for long\u2010term inhibition of infection and encrustation in urinary catheters"],"prefix":"10.1002","volume":"103","author":[{"given":"Rong","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Chemical and Biomolecular Engineering National University of Singapore Kent Ridge Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koon Gee","family":"Neoh","sequence":"additional","affiliation":[{"name":"Department of Chemical and Biomolecular Engineering National University of Singapore Kent Ridge Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"En\u2010Tang","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Chemical and Biomolecular Engineering National University of Singapore Kent Ridge Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul Anantharajah","family":"Tambyah","sequence":"additional","affiliation":[{"name":"Department of Medicine National University of Singapore Kent Ridge Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edmund","family":"Chiong","sequence":"additional","affiliation":[{"name":"Department of Surgery National University of Singapore Kent Ridge Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,6,12]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5520(03)00011-4"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(03)00325-X"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00019-07"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1089\/end.2004.18.891"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/sc.2010.32"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.4161\/viru.2.5.17783"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)49707-2"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2648.1994.20010140.x"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1089\/end.2011.0385"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOU.0b013e328323d6d2"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2010.07.036"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(06)00252-7"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2011.10903.x"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/2049-632X.12141"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201205923"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00240-002-0252-7"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000168618.79096.cb"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.33106"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.012419-0"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00240-009-0176-6"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61380-4"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1147241"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1039\/c1nr10969c"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1039\/c1cc15048k"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1021\/am200978h"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2007.05.041"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0600938103"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/bit.23342"},{"key":"e_1_2_5_30_1","unstructured":"International Organization for Standardization (ISO). Biological evaluation of medical devices\u2010Part 5: Tests forin vitrocytotoxicity. ISO 10993\u20105:2009(E). International Organization for Standardization (ISO); 2009. pp. 1\u201334."},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1021\/es400396f"},{"key":"e_1_2_5_32_1","doi-asserted-by":"crossref","unstructured":"GouldCV UmscheidCA AgarwalRK KuntzG PeguesDA the Healthcare Infection Control Practices Advisory Committee (HICPAC). Guideline for prevention of catheter\u2010associated urinary tract infections 2009. Centers for Disease Control and Prevention US Department of Health and Human Services; 2009. pp. 1\u201367.","DOI":"10.1086\/651091"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1021\/la303438t"}],"container-title":["Journal of Biomedical Materials Research Part B: Applied Biomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjbm.b.33230","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjbm.b.33230","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbm.b.33230","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jbm.b.33230","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbm.b.33230","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T01:36:14Z","timestamp":1693964174000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbm.b.33230"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6,12]]},"references-count":32,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,4]]}},"alternative-id":["10.1002\/jbm.b.33230"],"URL":"https:\/\/doi.org\/10.1002\/jbm.b.33230","archive":["Portico"],"relation":{},"ISSN":["1552-4973","1552-4981"],"issn-type":[{"value":"1552-4973","type":"print"},{"value":"1552-4981","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6,12]]}}}