{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:16:16Z","timestamp":1791216976870,"version":"4.1.0"},"reference-count":49,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,6,26]],"date-time":"2014-06-26T00:00:00Z","timestamp":1403740800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001808","name":"Commission for Technology and Innovation","doi-asserted-by":"crossref","award":["13731.1 PFFLM-LS"],"award-info":[{"award-number":["13731.1 PFFLM-LS"]}],"id":[{"id":"10.13039\/501100001808","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Biomed Mater Res"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>CoCr alloys, in particular MP35N and L605, are extensively used in biomedical implants, for example for coronary stents. In practice, these alloys present a moderately hydrophobic surface which leads to significant platelet adhesion and consequently to risk of early thrombosis or in\u2010stent restenosis. Surface modification of biomedical implants is known to alter their biological performances. In this study we focused on the alteration of<jats:italic>in vitro<\/jats:italic>biological responses of human cells contacting CoCr surfaces with engineered oxide layers. XPS analysis was performed to determine the composition of the oxide layer of differently treated CoCr while the bulk properties were not modified. An extensive characterization of the surfaces was performed looking at surface roughness, wettability and charge. After static exposure to blood, strongly reduced platelet and increased polymorphonuclear neutrophil adhesion were observed on treated versus untreated surfaces. Comparisons of treated and untreated samples provide evidence for wettability being an important player for platelet adhesion, although multiple factors including surface oxide chemistry and charge might control polymorphonuclear neutrophil adhesion. The differently treated surfaces were shown to be equally suitable for endothelial cell proliferation. We herein present a novel approach to steer biological properties of CoCr alloys. By adjusting their oxide layer composition, substrates were generated which are suitable for endothelial cell growth and at the same time show an altered (reduced) blood contact activation. Such treatments are expected to lead to stents of highly reproducible quality with minimal thrombogenicity and in\u2010stent restenosis, while maintaining rapid re\u2010endothelialization after coronary angioplasty. \u00a9 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 103B: 629\u2013640, 2015.<\/jats:p>","DOI":"10.1002\/jbm.b.33232","type":"journal-article","created":{"date-parts":[[2014,6,26]],"date-time":"2014-06-26T11:08:32Z","timestamp":1403780912000},"page":"629-640","source":"Crossref","is-referenced-by-count":29,"title":["Effect of oxide layer modification of CoCr stent alloys on blood activation and endothelial behavior"],"prefix":"10.1002","volume":"103","author":[{"given":"Vincent","family":"Milleret","sequence":"first","affiliation":[{"name":"Department of Obstetrics University Hospital Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Algirdas","family":"Ziogas","sequence":"additional","affiliation":[{"name":"Department of Obstetrics University Hospital Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Buzzi","sequence":"additional","affiliation":[{"name":"Qvanteq AG Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roman","family":"Heuberger","sequence":"additional","affiliation":[{"name":"RMS Foundation Bettlach Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arik","family":"Zucker","sequence":"additional","affiliation":[{"name":"Qvanteq AG Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Ehrbar","sequence":"additional","affiliation":[{"name":"Department of Obstetrics University Hospital Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,6,26]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2006.11.042"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2008.11.012"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.294.10.1215"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16850-5"},{"key":"e_1_2_7_6_1","first-page":"688","article-title":"Vascular endothelial growth factor (VEGF)\u2010eluting stents: In vivo effects on thrombosis, endothelialization and intimal hyperplasia","volume":"15","author":"Swanson N","year":"2003","journal-title":"J Invasive Cardiol"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2011.05.025"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1076-6332(05)80338-1"},{"key":"e_1_2_7_9_1","doi-asserted-by":"crossref","unstructured":"AmonM BolzA HeubleinB SchaldachM. Coating of cardiovascular stent with amorphous silicon carbide to reduce thrombogenicity. Proceedings of the 16th Annual International Conference of the Ieee Engineering in Medicine and Biology Society\u2014Engineering Advances: New Opportunities for Biomedical Engineers Pts 1&2.1994:838\u2013839.","DOI":"10.1109\/IEMBS.1994.415171"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/hc3401.093146"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2012.02.010"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.91.12.2995"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.03.042"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2012.758"},{"key":"e_1_2_7_15_1","first-page":"71","article-title":"Scanning electron microscopic analysis of defects in polymer coatings of three commercially available stents: Comparison of BiodivYsio, Taxus and Cypher stents","volume":"19","author":"Otsuka Y","year":"2007","journal-title":"J Invasive Cardiol"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJV7I7A131"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2010.04.018"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0142-9612(94)90038-8"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2003.10.070"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2012.05.010"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2003.09.048"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.08.674"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2010.01.014"},{"key":"e_1_2_7_24_1","doi-asserted-by":"crossref","unstructured":"BilekMMM BaxDV KondyurinA YinY NosworthyNJ FisherK WatherhouseA WeissAS dos RemediosCG McKenzieDR. Free radical functionalization of surfaces to prevent adverse responses to biomedical devices. Proceedings of the National Academy of Sciences of the United States of America2011;108.","DOI":"10.1073\/pnas.1103277108"},{"key":"e_1_2_7_25_1","volume-title":"Auger and X\u2010ray Photoelectron Spectroscopy","author":"Briggs D","year":"1990"},{"key":"e_1_2_7_26_1","volume-title":"Handbook of X\u2010Ray Photoelectron Spectroscopy","author":"Moulder JF","year":"1995"},{"key":"e_1_2_7_27_1","first-page":"1199","article-title":"Wettability analysis of orthopaedic materials using optical contact angle methods","volume":"309","author":"Salehi A","year":"2006","journal-title":"Bioceramics"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr60234a002"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cis.2009.08.003"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1163\/016942409X12598231568186"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2012.07.032"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.22203\/eCM.v021a32"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2011.10.059"},{"key":"e_1_2_7_34_1","first-page":"254","article-title":"Platelet adhesion on metal oxide layers","volume":"16","author":"Takemoto S","year":"2004","journal-title":"Bioceramics"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4636(199808)41:2<304::AID-JBM16>3.0.CO;2-K"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2005.04.042"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2009.10.008"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1021\/la204777x"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.32480"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2003.09.047"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2009.12.016"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117974"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-05-283564"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1614630"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1708-8208.2011.00362.x"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1021\/nl0482635"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.113.000120"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3002531"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.111.257535"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2009.10.028"}],"container-title":["Journal of Biomedical Materials Research Part B: Applied Biomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjbm.b.33232","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjbm.b.33232","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbm.b.33232","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jbm.b.33232","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbm.b.33232","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,3]],"date-time":"2025-05-03T13:28:29Z","timestamp":1746278909000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbm.b.33232"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6,26]]},"references-count":49,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,4]]}},"alternative-id":["10.1002\/jbm.b.33232"],"URL":"https:\/\/doi.org\/10.1002\/jbm.b.33232","archive":["Portico"],"relation":{},"ISSN":["1552-4973","1552-4981"],"issn-type":[{"value":"1552-4973","type":"print"},{"value":"1552-4981","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6,26]]}}}