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The purpose of this study was to develop and characterize an endodontic sealer based on a glycerol salicylate resin and \u03b1\u2010tricalcium phosphate (\u03b1TCP) at physical and chemical properties. Different sealers were formulated using 70% of a glycerol salicylate resin and 30% of a mixture of calcium hydroxide and \u03b1TCP (0, 5, 10, or 15%, in weight). Sealers formulated were characterized based on setting time, <jats:italic>in vitro<\/jats:italic> degradation over time, pH, cytotoxicity, and mineral deposition. Sealers presented setting time ranging from 240 to 405 min, and basic pH over 8.21 after 28 days. Higher \u03b1TCP concentration leads to sealers with low solubility. Cell viability after 48 h in direct contact with sealers was similar to a commercial sealer used as reference. The 10% and 15% \u03b1TCP sealers exhibited a calcium\u2013phosphate layer on the surface after immersion in water and SBF for 7 days. Glycerol salicylate sealers with 10% and 15% \u03b1\u2010tricalcium phosphate showed reliable physical\u2013chemical properties and apatite\u2010forming ability. \u00a9 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 103B: 1663\u20131669, 2015.<\/jats:p>","DOI":"10.1002\/jbm.b.33326","type":"journal-article","created":{"date-parts":[[2015,1,21]],"date-time":"2015-01-21T19:56:38Z","timestamp":1421870198000},"page":"1663-1669","source":"Crossref","is-referenced-by-count":23,"title":["Glycerol salicylate\u2010based containing \u03b1\u2010tricalcium phosphate as a bioactive root canal sealer"],"prefix":"10.1002","volume":"103","author":[{"given":"Fernando F.","family":"Portella","sequence":"first","affiliation":[{"name":"Dental Materials Laboratory School of Dentistry, Federal University of Rio Grande do Sul Porto Alegre RS Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabr\u00edcio M.","family":"Collares","sequence":"additional","affiliation":[{"name":"Dental Materials Laboratory School of Dentistry, Federal University of Rio Grande do Sul Porto Alegre RS Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu\u00eds A.","family":"dos Santos","sequence":"additional","affiliation":[{"name":"Biomaterials Laboratory Department of Materials Federal University of Rio Grande do Sul Porto Alegre RS Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno P.","family":"dos Santos","sequence":"additional","affiliation":[{"name":"Laboratory of Stem Cells and Tissue Engineering Universidade Luterana do Brasil Canoas RS Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Camassola","sequence":"additional","affiliation":[{"name":"Laboratory of Stem Cells and Tissue Engineering Universidade Luterana do Brasil Canoas RS Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicente C. 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