{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T01:22:12Z","timestamp":1789953732677,"version":"4.0.1"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,2,6]],"date-time":"2015-02-06T00:00:00Z","timestamp":1423180800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002322","name":"CAPES","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004586","name":"FAPERJ","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Biomed Mater Res"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Guided tissue regeneration is a technique used for periodontium reconstruction. This technique uses barrier membranes, which prevent epithelial growth in the wound site and may also be used to release antibiotics, to protect the wound against opportunistic infections. Periodontal poly(3\u2010hydroxybutyrate) membranes containing metronidazole (a drug used to help in infection control) were produced and characterized. The kinetic mechanism of the metronidazole delivery of leached and nonleached membrane as well as its cytotoxicity and structural integrity were evaluated. Poly(3\u2010hydroxybutyrate) membranes containing 0.5\u20132 wt % of the drug and 20 wt % of the plasticizer were manufactured via compression molding. Based on morphological analysis, membranes loaded with 2% metronidazole were considered for detailed studies. The results revealed that metronidazole delivery by the leached membranes seemed to follow the Fick's law. Membranes were noncytotoxic. The amount of metronidazole delivered was in the range of the minimal inhibitory concentration for\n                    <jats:italic>Porphyromonas gingivalis<\/jats:italic>\n                    , and the membranes inhibited the proliferation of these bacteria. Besides, they maintained their mechanical resistance after 30 days of immersion in phosphate buffer at pH 7.4. \u00a9 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 104B: 106\u2013115, 2016.\n                  <\/jats:p>","DOI":"10.1002\/jbm.b.33357","type":"journal-article","created":{"date-parts":[[2015,2,6]],"date-time":"2015-02-06T04:53:36Z","timestamp":1423198416000},"page":"106-115","source":"Crossref","is-referenced-by-count":22,"title":["Evaluation of metronidazole\u2010loaded poly(3\u2010hydroxybutyrate) membranes to potential application in periodontitis treatment"],"prefix":"10.1002","volume":"104","author":[{"given":"Marcio A. C.","family":"da Silva","sequence":"first","affiliation":[{"name":"COPPE\/Program of Metallurgical and Materials Engineering, Federal University of Rio de Janeiro Rio de Janeiro City, Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata N.","family":"Oliveira","sequence":"additional","affiliation":[{"name":"COPPE\/Program of Metallurgical and Materials Engineering, Federal University of Rio de Janeiro Rio de Janeiro City, Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta Helena","family":"Mendon\u00e7a","sequence":"additional","affiliation":[{"name":"Chemical Engineering Department of the Technology Institute, Federal Rural University of Rio de Janeiro Rio de Janeiro City, Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Talita G. B.","family":"Louren\u00e7o","sequence":"additional","affiliation":[{"name":"Institute of Microbiology Paulo de G\u00f3es, Centre of Health Sciences, Federal University of Rio de Janeiro Rio de Janeiro City, Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Paula V.","family":"Colombo","sequence":"additional","affiliation":[{"name":"Institute of Microbiology Paulo de G\u00f3es, Centre of Health Sciences, Federal University of Rio de Janeiro Rio de Janeiro City, Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo N.","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Bioceramics and Cell Culture Lab, Brazilian Center for Physics Research Rio de Janeiro City, Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena M. 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