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We prepared a double\u2010layered electrospun nanofibrous sheets composed of Eudragit and chitosan to accelerate the healing rate of oral mucous ulcer. Human growth hormone (hGH) and Eudragit in a mixture of dimethylacetamide and ethanol were co\u2010electrospun to nanofibrous sheets. The electrospun fibrous mat was subsequently layered with chitosan by a dip\u2010coating method. Chitosan\u2010layered sheets showed attenuated mass erosion while uncoated sheets were instantly melted at the physiological condition. The released hGH was trapped on the chitosan layer by the ionic interaction between positively charged chitosan and negatively charged hGH, and a large number of entrapped proteins remained on the SIS membrane due to the muco\u2010adhesive properties of chitosan. hGH\u2010incorporated sheets significantly increased proliferation of human dermal fibroblasts. In vivo study employing oral ulcers in dogs, the ulcers dressed with chitosan\u2010layered sheets showed enhanced wound recovery and the chitosan layers on the sheet greatly assisted prolonged recovery. Therefore, chitosan\u2010layered Eudragit nanofibrous sheets can be potentially applied to developing muco\u2010adhesive wound dressing materials with pH\u2010dependent drug release by adjusting the thickness of chitosan sheath on the sheets. \u00a9 2015 Wiley Periodicals, Inc. 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