{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T12:52:12Z","timestamp":1790686332927,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,7,31]],"date-time":"2015-07-31T00:00:00Z","timestamp":1438300800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Biomed Mater Res"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Completely autologous <jats:italic>in vivo<\/jats:italic> tissue\u2010engineered connective tissue tubes (Biotubes) have promise as arterial vascular grafts in animal implantation studies. In this clinical study of patients undergoing peritoneal dialysis (PD) (<jats:italic>n<\/jats:italic>\u2009=\u200911; age: 39\u201383 years), we evaluated human Biotubes' (h\u2010Biotubes) mechanical properties to determine whether Biotubes with feasibility as vascular grafts could be formed in human bodies. We extracted PD catheters, embedded for 4\u201347 months, and obtained tubular connective tissues as h\u2010Biotubes (internal diameter: 5 mm) from around the catheter' silicone tubular parts. h\u2010Biotubes were composed mainly of collagen with smooth luminal surfaces. The average wall thickness was 278\u2009\u00b1\u2009178 \u03bcm. No relationship was founded between the tubes' mechanical properties and patients' ages or PD catheter embedding periods statistically. However, the elastic modulus (2459\u2009\u00b1\u2009970 kPa) and tensile strength (623\u2009\u00b1\u2009314 g) of h\u2010Biotubes were more than twice as great as those from animal Biotubes, formed from the same PD catheters by embedding in the beagle subcutaneous pouches for 1 month, or beagle arteries. The burst strength (6338\u2009\u00b1\u20091106 mmHg) of h\u2010Biotubes was almost the same as that of the beagle thoracic or abdominal aorta. h\u2010Biotubes could be formed in humans over a 4\u2010month embedding period, and they satisfied the mechanical requirements for application as vascular grafts. \u00a9 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 104B: 1431\u20131437, 2016.<\/jats:p>","DOI":"10.1002\/jbm.b.33495","type":"journal-article","created":{"date-parts":[[2015,7,31]],"date-time":"2015-07-31T05:49:03Z","timestamp":1438321743000},"page":"1431-1437","source":"Crossref","is-referenced-by-count":19,"title":["Mechanical properties of human autologous tubular connective tissues (human biotubes) obtained from patients undergoing peritoneal dialysis"],"prefix":"10.1002","volume":"104","author":[{"given":"Yasuhide","family":"Nakayama","sequence":"first","affiliation":[{"name":"Division of Medical Engineering and Materials National Cerebral and Cardiovascular Center Research Institute Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiyuki","family":"Kaneko","sequence":"additional","affiliation":[{"name":"Department of Kidney and Dialysis Tenri Hospital Nara 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