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A bioprosthetic venous valve could not only replace a diseased valve, but has the potential to fully integrate into the patient with a minimally invasive procedure. Previous work with valves constructed from small intestinal submucosa (SIS) showed improvements in patients' symptoms in clinical studies; however, substantial thickening of the implanted valve leaflets also occurred. As endothelial cells are key regulators of vascular homeostasis, their presence on the SIS valves may reduce the observed thickening. This work tested an off\u2010the\u2010shelf approach to capture circulating endothelial cells <jats:italic>in vivo<\/jats:italic> using biotinylated antikinase insert domain receptor antibodies in a suspended leaflet ovine model. The antibodies on SIS were oriented to promote cell capture and showed positive binding to endothelial cells <jats:italic>in vitro<\/jats:italic>; however, no differences were observed in leaflet thickness <jats:italic>in vivo<\/jats:italic> between antibody\u2010modified and unmodified SIS. In an alternative approach, valves were pre\u2010seeded with autologous endothelial cells and tested <jats:italic>in vivo<\/jats:italic>. Nearly all the implanted pre\u2010seeded valves were patent and functioning; however, no statistical difference was observed in valve thickness with cell pre\u2010seeding. Additional cell capture schemes or surface modifications should be examined to find an optimal method for encouraging SIS valve endothelialization to improve long\u2010term valve function <jats:italic>in vivo<\/jats:italic>. \u00a9 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 104B: 1610\u20131621, 2016.<\/jats:p>","DOI":"10.1002\/jbm.b.33507","type":"journal-article","created":{"date-parts":[[2015,8,28]],"date-time":"2015-08-28T15:54:49Z","timestamp":1440777289000},"page":"1610-1621","source":"Crossref","is-referenced-by-count":7,"title":["<i>In vivo<\/i> assessment of two endothelialization approaches on bioprosthetic valves for the treatment of chronic deep venous insufficiency"],"prefix":"10.1002","volume":"104","author":[{"given":"Jeremy J.","family":"Glynn","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering Oregon Health &amp; Science University Portland Oregon 97239"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Casey M.","family":"Jones","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Oregon Health &amp; Science University Portland Oregon 97239"},{"name":"Department of Chemistry Lewis &amp; Clark College Portland Oregon 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