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The currently practiced trabeculectomy surgery, the gold standard treatment used to stop the progression of vision loss, is rather draconian, traumatic to the patient and requires much surgical skill to perform. This article summarizes the more than 10\u2010year development path of a novel device called the InnFocus MicroShunt\u00ae, which is a minimally invasive glaucoma drainage micro\u2010tube used to shunt aqueous humor from the anterior chamber of the eye to a flap formed under the conjunctiva and Tenon's Capsule. The safety and clinical performance of this device approaches that of trabeculectomy. The impetus to develop this device stemmed from the invention of a new biomaterial called poly(styrene\u2010<jats:italic>block<\/jats:italic>\u2010isobutylene\u2010<jats:italic>block<\/jats:italic>\u2010styrene), or \u201cSIBS.\u201d SIBS is ultra\u2010stable with virtually no foreign body reaction in the body, which manifests in the eye as clinically insignificant inflammation and capsule formation. The quest for an easier, safer, and more effective method of treating glaucoma led to the marriage of SIBS with this glaucoma drainage micro\u2010tube. This article summarizes the development of SIBS and the subsequent three iterations of design and four clinical trials that drove the one\u2010year qualified success rate of the device from 43% to 100%. \u00a9 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 211\u2013221, 2017.<\/jats:p>","DOI":"10.1002\/jbm.b.33525","type":"journal-article","created":{"date-parts":[[2015,9,18]],"date-time":"2015-09-18T09:49:51Z","timestamp":1442569791000},"page":"211-221","source":"Crossref","is-referenced-by-count":153,"title":["The development of a micro\u2010shunt made from poly(styrene\u2010<i>block<\/i>\u2010isobutylene\u2010<i>block<\/i>\u2010styrene) to treat glaucoma"],"prefix":"10.1002","volume":"105","author":[{"given":"Leonard","family":"Pinchuk","sequence":"first","affiliation":[{"name":"InnFocus, Inc. Miami Florida"},{"name":"Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine Miami Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Riss","sequence":"additional","affiliation":[{"name":"P\u00f4le Ophtalmologique de la Clinique Mutualiste Pessac Cedex France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan F.","family":"Batlle","sequence":"additional","affiliation":[{"name":"Centro Laser Santo Domingo Dominican Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasushi P.","family":"Kato","sequence":"additional","affiliation":[{"name":"InnFocus, Inc. Miami Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John B.","family":"Martin","sequence":"additional","affiliation":[{"name":"InnFocus, Inc. 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