{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T10:44:30Z","timestamp":1786963470478,"version":"build-2736575974"},"reference-count":41,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,4,15]],"date-time":"2016-04-15T00:00:00Z","timestamp":1460678400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Harris Orthopedic Laboratory"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Biomed Mater Res"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Radiation crosslinked ultrahigh molecular weight polyethylene (UHMWPE) is the bearing surface material most commonly used in total joint arthroplasty because of its excellent wear resistance. Crosslinking agents such as peroxides can also effectively increase wear resistance but peroxide crosslinked UHMWPE has low oxidative stability. We hypothesized that the addition of an antioxidant to peroxide crosslinked UHMWPE could improve its oxidation resistance and result in mechanical, tribological, and oxidative properties equivalent to currently utilized radiation crosslinked UHMWPEs. Various vitamin E (0.1\u20131.0 wt % and peroxide concentration (0.5\u20131.5 wt %) combinations were studied to investigate changes in crosslink density, wear rate, mechanical properties, and oxidative stability in comparison to radiation crosslinked UHMWPE. Peroxide crosslinking was more efficient as compared to radiation crosslinking in the presence of vitamin E with the former resulting in lower wear rate with vitamin E concentrations above 0.3 wt %. The tensile mechanical properties were comparable to and the impact strength was higher than those of the clinically relevant radiation crosslinked controls. We also determined that gamma sterilization of peroxide crosslinked vitamin E blends improved wear resistance further. In summary, peroxide crosslinking of vitamin E\u2010blended UHMWPE may provide a feasible and economical alternative to radiation for achieving clinically relevant properties for total joint implants using UHMWPE. \u00a9 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 1379\u20131389, 2017.<\/jats:p>","DOI":"10.1002\/jbm.b.33662","type":"journal-article","created":{"date-parts":[[2016,4,15]],"date-time":"2016-04-15T07:52:30Z","timestamp":1460706750000},"page":"1379-1389","source":"Crossref","is-referenced-by-count":23,"title":["Peroxide cross\u2010linked UHMWPE blended with vitamin E"],"prefix":"10.1002","volume":"105","author":[{"given":"Ebru","family":"Oral","sequence":"first","affiliation":[{"name":"Harris Orthopedic Laboratory Massachusetts General Hospital, Boston, Massachusetts"},{"name":"Harvard Medical School Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brinda N.","family":"Doshi","sequence":"additional","affiliation":[{"name":"Harris Orthopedic Laboratory Massachusetts General Hospital, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rizwan M.","family":"Gul","sequence":"additional","affiliation":[{"name":"Harris Orthopedic Laboratory Massachusetts General Hospital, Boston, Massachusetts"},{"name":"Department of Mechanical Engineering University of Engineering and Technology Peshawar Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew L.","family":"Neils","sequence":"additional","affiliation":[{"name":"Harris Orthopedic Laboratory Massachusetts General Hospital, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanem","family":"Kayandan","sequence":"additional","affiliation":[{"name":"Harris Orthopedic Laboratory Massachusetts General Hospital, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orhun K.","family":"Muratoglu","sequence":"additional","affiliation":[{"name":"Harris Orthopedic Laboratory Massachusetts General Hospital, Boston, Massachusetts"},{"name":"Harvard Medical School Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,4,15]]},"reference":[{"key":"e_1_2_7_2_1","volume-title":"First Annual Report on Hip and Knee Arthroplasty Data (2013)","author":"Registry AJR","year":"2014"},{"key":"e_1_2_7_3_1","volume-title":"2007 Annual report","author":"Registry CJR","year":"2007"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-011-1872-4"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-374721-1.00020-1"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/00222349508215534"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0142-9612(95)00349-5"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.blo.0000246547.18187.0b"},{"key":"e_1_2_7_9_1","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1097\/01.blo.0000093004.90435.d1","article-title":"Effect of radiation, heat, and aging on in vitro wear resistance of polyethylene","volume":"417","author":"Muratoglu OK","year":"2003","journal-title":"Clin Orthop Relat Res"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1088\/0022-3727\/39\/15\/S12"},{"key":"e_1_2_7_11_1","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1002\/jbm.b.32805","article-title":"In vivo oxidation in retrieved highly crosslinked tibial inserts","volume":"101","author":"Currier B","year":"2013","journal-title":"J Biomed Mater Res"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-010-1717-6"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-014-4108-6"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2008.05.004"},{"key":"e_1_2_7_15_1","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1002\/jbm.b.32807","article-title":". Increasing irradiation temperature maximizes vitamin E grafting and wear resistance of UHMWPE","volume":"101","author":"Oral E","year":"2013","journal-title":"J Biomed Mater Res"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radphyschem.2014.05.017"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2003.12.048"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2005.07.009"},{"key":"e_1_2_7_19_1","unstructured":"GreeneM BragdonC KwonY\u2010M RubashH MalchauH.Three year evaluation of the wear of vitamin E stabilized highly crosslinked polyethylene the stability of Regenerex acetabular shells and femoral components with 32 mm heads. Transactions of the Annual Meeting of the American Academy of Orthopaedic Surgeons2012; San Francisco CA. p1071."},{"key":"e_1_2_7_20_1","doi-asserted-by":"crossref","unstructured":"Sillesen N Greene M Nebergall A Nielsen PT Laursen MB Troelsen A Malchau H. Three Year RSA Evaluation of Vitamin E Diffused Highly Cross\u2010linked Polyethylene Liners and Cup Stability. J Arthroplasty 2015;30:1260\u20131264.","DOI":"10.1016\/j.arth.2015.02.018"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.I.01006"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.32507"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-015-4153-9"},{"key":"e_1_2_7_24_1","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1201\/9781482295467","volume-title":"Handbook of Polyethylene: Structure, Properties and Applications","author":"Peacock A.","year":"2000"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(99)00039-3"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-0488(19960430)34:6<1063::AID-POLB4>3.0.CO;2-Z"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4636(199807)41:1<71::AID-JBM9>3.0.CO;2-N"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.blo.0000149999.17123.e8"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10856-008-3368-7"},{"key":"e_1_2_7_30_1","first-page":"1037","article-title":"Highly cross\u2010linked UHMWPE with improved fatigue resistance for total joint arthroplasty","volume":"23","author":"Oral E","year":"2008","journal-title":"J Arthroplasty (Winner of the 2006 'HAP' Paul Award)"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2009.04.005"},{"key":"e_1_2_7_32_1","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1201\/9781482295467","volume-title":"Handbook of Polyethylene\u2014Structure, Properties and Applications","author":"Peacock A.","year":"2000"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2010.05.041"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-011-5862-6"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2007.08.025"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1019892004830"},{"key":"e_1_2_7_37_1","first-page":"393","article-title":"The 2012 Charnley Award: Clinical multicenter studies of the wear performance of highly crosslinked remelted polyethylene in THA. Clin","volume":"471","author":"Bragdon C","year":"2013","journal-title":"Orthop"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2008.12.029"},{"key":"e_1_2_7_39_1","unstructured":"NeilsA OralE MuratogluO.The initial concentration of vitamin E in irradiated UHMWPE affects vitamin E grafting. Transactions of the Annual Meeting of the Orthopaedic Research Society.2013; San Antonio TX. p1818."},{"key":"e_1_2_7_40_1","unstructured":"OralE RowellS MuratogluO.Oxidation resistance of Vitamin E\u2010doped irradiated UHMWPE for total joints following forceful extraction of vitamin E. Transactions of the Annual Meeting of the Orthopaedic Research Society.2006; Chicago IL. p665."},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2004.03.022"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.23168"}],"container-title":["Journal of Biomedical Materials Research Part B: Applied Biomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjbm.b.33662","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjbm.b.33662","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbm.b.33662","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,15]],"date-time":"2024-06-15T19:51:31Z","timestamp":1718481091000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbm.b.33662"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4,15]]},"references-count":41,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,8]]}},"alternative-id":["10.1002\/jbm.b.33662"],"URL":"https:\/\/doi.org\/10.1002\/jbm.b.33662","archive":["Portico"],"relation":{},"ISSN":["1552-4973","1552-4981"],"issn-type":[{"value":"1552-4973","type":"print"},{"value":"1552-4981","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,4,15]]}}}