{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T18:36:30Z","timestamp":1759775790649,"version":"3.37.3"},"reference-count":35,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2016,5,26]],"date-time":"2016-05-26T00:00:00Z","timestamp":1464220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2016,5,26]],"date-time":"2016-05-26T00:00:00Z","timestamp":1464220800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003744","name":"Hjalmar Svensson Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003744","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001327","name":"Society for Endocrinology, Metabolism and Diabetes of South Africa","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001327","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Royal and Hvitfeldtska Foundation"},{"DOI":"10.13039\/501100005301","name":"Swedish Dental Society","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005301","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Biomed. Mater. Res."],"published-print":{"date-parts":[[2017,10]]},"DOI":"10.1002\/jbm.b.33717","type":"journal-article","created":{"date-parts":[[2016,5,26]],"date-time":"2016-05-26T17:21:15Z","timestamp":1464283275000},"page":"1847-1854","source":"Crossref","is-referenced-by-count":3,"title":["Insulin released from titanium discs with insulin coatings-Kinetics and biological activity"],"prefix":"10.1002","volume":"105","author":[{"given":"B. \u00d6.","family":"Malekzadeh","sequence":"first","affiliation":[{"name":"Department of Orthodontics; Institute of Odontology, Sahlgrenska Academy, University of Gothenburg; Gothenburg Sweden"},{"name":"Department of Oral and Maxillofacial Surgery; M\u00f6lndal Hospital; Sweden"},{"name":"Department of Biomaterials; Sahlgrenska Academy, University of Gothenburg; Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Ransjo","sequence":"additional","affiliation":[{"name":"Department of Orthodontics; Institute of Odontology, Sahlgrenska Academy, University of Gothenburg; Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Tengvall","sequence":"additional","affiliation":[{"name":"Department of Biomaterials; Sahlgrenska Academy, University of Gothenburg; Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z.","family":"Mladenovic","sequence":"additional","affiliation":[{"name":"Department of Orthodontics; Institute of Odontology, Sahlgrenska Academy, University of Gothenburg; Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Westerlund","sequence":"additional","affiliation":[{"name":"Department of Orthodontics; Institute of Odontology, Sahlgrenska Academy, University of Gothenburg; Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,5,26]]},"reference":[{"key":"10.1002\/jbm.b.33717-BIB0001|jbmb33717-cit-0002","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1002\/jbmr.5650040610","article-title":"The characterization, regulation, and function of insulin receptors on osteoblast-like clonal osteosarcoma cell line","volume":"4","author":"Pun","year":"1989","journal-title":"J Bone Miner Res"},{"key":"10.1002\/jbm.b.33717-BIB0002|jbmb33717-cit-0003","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1002\/jbmr.5650110916","article-title":"Insulin receptor expression in bone","volume":"11","author":"Thomas","year":"1996","journal-title":"J Bone Miner Res"},{"key":"10.1002\/jbm.b.33717-BIB0003|jbmb33717-cit-0004","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.1210\/endo-119-4-1786","article-title":"Demonstration of insulin receptors and modulation of alkaline phosphatase activity by insulin in rat osteoblastic cells","volume":"119","author":"Levy","year":"1986","journal-title":"Endocrinology"},{"key":"10.1002\/jbm.b.33717-BIB0004|jbmb33717-cit-0005","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1002\/cbf.1668","article-title":"Insulin stimulates osteoblast proliferation and differentiation through ERK and PI3K in MG-63 cells","volume":"28","author":"Yang","year":"2010","journal-title":"Cell Biochem Funct"},{"key":"10.1002\/jbm.b.33717-BIB0005|jbmb33717-cit-0006","doi-asserted-by":"crossref","first-page":"2394","DOI":"10.1097\/BRS.0b013e3181838fe5","article-title":"Insulin potentiates the proliferation and bone morphogenetic protein-2-induced osteogenic differentiation of rat spinal ligament cells via extracellular signal-regulated kinase and phosphatidylinositol 3-kinase","volume":"33","author":"Li","year":"2008","journal-title":"Spine (Phila PA 1976)"},{"key":"10.1002\/jbm.b.33717-BIB0006|jbmb33717-cit-0007","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.cell.2010.06.002","article-title":"Insulin receptor signaling in osteoblasts regulates postnatal bone acquisition and body composition","volume":"142","author":"Fulzele","year":"2010","journal-title":"Cell"},{"key":"10.1002\/jbm.b.33717-BIB0007|jbmb33717-cit-0008","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1002\/cbf.2801","article-title":"Effects of insulin and insulin-like growth factor 1 on osteoblast proliferation and differentiation: Differential signalling via Akt and ERK","volume":"30","author":"Zhang","year":"2012","journal-title":"Cell Biochem Funct"},{"key":"10.1002\/jbm.b.33717-BIB0008|jbmb33717-cit-0009","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1002\/jor.22288","article-title":"Effects of local insulin delivery on subperiosteal angiogenesis and mineralized tissue formation during fracture healing","volume":"31","author":"Paglia","year":"2013","journal-title":"J Orthop Res"},{"key":"10.1002\/jbm.b.33717-BIB0009|jbmb33717-cit-0010","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1007\/s11427-012-4392-x","article-title":"Sustained local delivery of insulin for potential improvement of peri-implant bone formation in diabetes","volume":"55","author":"Han","year":"2012","journal-title":"Sci China Life Sci"},{"key":"10.1002\/jbm.b.33717-BIB0010|jbmb33717-cit-0011","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.cell.2010.06.003","article-title":"Insulin signaling in osteoblasts integrates bone remodeling and energy metabolism","volume":"142","author":"Ferron","year":"2010","journal-title":"Cell"},{"key":"10.1002\/jbm.b.33717-BIB0011|jbmb33717-cit-0012","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.cell.2007.05.047","article-title":"Endocrine regulation of energy metabolism by the skeleton","volume":"130","author":"Lee","year":"2007","journal-title":"Cell"},{"key":"10.1002\/jbm.b.33717-BIB0012|jbmb33717-cit-0013","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1002\/jbmr.321","article-title":"The osteoblast: An insulin target cell controlling glucose homeostasis","volume":"26","author":"Clemens","year":"2011","journal-title":"J Bone Miner Res"},{"key":"10.1002\/jbm.b.33717-BIB0013|jbmb33717-cit-0014","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.bone.2005.04.039","article-title":"The effects of local insulin delivery on diabetic fracture healing","volume":"37","author":"Gandhi","year":"2005","journal-title":"Bone"},{"key":"10.1002\/jbm.b.33717-BIB0014|jbmb33717-cit-0015","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1002\/jor.21205","article-title":"Role of local insulin augmentation upon allograft incorporation in a rat femoral defect model","volume":"29","author":"Dedania","year":"2011","journal-title":"J Orthop Res"},{"key":"10.1002\/jbm.b.33717-BIB0015|jbmb33717-cit-0016","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.spinee.2012.11.030","article-title":"The effects of local insulin application to lumbar spinal fusions in a rat model","volume":"13","author":"Koerner","year":"2013","journal-title":"Spine J"},{"key":"10.1002\/jbm.b.33717-BIB0016|jbmb33717-cit-0017","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.bjoms.2010.03.006","article-title":"Effects of local infiltration of insulin around titanium implants in diabetic rats","volume":"49","author":"Wang","year":"2011","journal-title":"Br J Oral Maxillofac Surg"},{"key":"10.1002\/jbm.b.33717-BIB0017|jbmb33717-cit-0018","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.ijpharm.2010.07.052","article-title":"Sustained prolonged topical delivery of bioactive human insulin for potential treatment of cutaneous wounds","volume":"398","author":"Hrynyk","year":"2010","journal-title":"Int J Pharm"},{"key":"10.1002\/jbm.b.33717-BIB0018|jbmb33717-cit-0019","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1002\/jor.22287","article-title":"Local insulin therapy affects fracture healing in a rat model","volume":"31","author":"Park","year":"2013","journal-title":"J Orthop Res"},{"key":"10.1002\/jbm.b.33717-BIB0019|jbmb33717-cit-0020","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1002\/jbm.a.34313","article-title":"Effect of local insulin administration on bone formation in non-diabetic rat","volume":"101","author":"Malekzadeh","year":"2013","journal-title":"J Biomed Mater Res A"},{"key":"10.1002\/jbm.b.33717-BIB0020|jbmb33717-cit-0021","first-page":"331","article-title":"Suggested guidelines for the topographic evaluation of implant surfaces","volume":"15","author":"Wennerberg","year":"2000","journal-title":"Int J Oral Maxillofac Implants"},{"key":"10.1002\/jbm.b.33717-BIB0021|jbmb33717-cit-0022","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/S0927-7765(02)00151-0","article-title":"Preparation of multilayer plasma protein films by EDS\/NHS coupling chemistry on silicon","volume":"28","author":"Tengvall","year":"2003","journal-title":"Colloids Surf B Biointerfaces"},{"key":"10.1002\/jbm.b.33717-BIB0022|jbmb33717-cit-0023","doi-asserted-by":"crossref","DOI":"10.6028\/NBS.TN.479","volume-title":"A Fortran Program for the Analysis of Ellipsometer Measurements","author":"McCrackin","year":"1969"},{"key":"10.1002\/jbm.b.33717-BIB0023|jbmb33717-cit-0024","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1002\/bip.1978.360170711","article-title":"Ellipsometry as a toll to study the adsorption of synthetic and biopolymers at the air-water interface","volume":"17","author":"Feijter","year":"1978","journal-title":"Biopolymers"},{"key":"10.1002\/jbm.b.33717-BIB0024|jbmb33717-cit-0025","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0927-7765(99)00136-8","article-title":"Quantification of adsorbed human serum albumin at solid interface: A comparison between radioimmunoassay (RIA) and simple null ellipsometery","volume":"18","author":"Benesch","year":"2000","journal-title":"Colloids Surf B: Biointerfaces"},{"key":"10.1002\/jbm.b.33717-BIB0025|jbmb33717-cit-0026","first-page":"83","article-title":"The use of the isoscpoe ellipsometer in the study of adsorbed proteins and biospecific binding reactions","volume":"C10","author":"Stenberg","year":"1983","journal-title":"J Phys C"},{"key":"10.1002\/jbm.b.33717-BIB0026|jbmb33717-cit-0027","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1038\/nprot.2008.75","article-title":"Neutral red uptake assay for the estimation of cell viability\/cytotoxicity","volume":"3","author":"Repetto","year":"2008","journal-title":"Nat Protoc"},{"key":"10.1002\/jbm.b.33717-BIB0027|jbmb33717-cit-0028","doi-asserted-by":"crossref","first-page":"9420","DOI":"10.1074\/jbc.270.16.9420","article-title":"Rapidly forming apatitic mineral in an osteoblastic cell line (UMR 106-01 BSP)","volume":"270","author":"Stanford","year":"1995","journal-title":"J Biol Chem"},{"key":"10.1002\/jbm.b.33717-BIB0028|jbmb33717-cit-0029","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.ab.2004.02.002","article-title":"An Alizarin red-based assay of mineralization by adherent cells in culture: Comparison with cetylpyridinium chloride extraction","volume":"329","author":"Gregory","year":"2004","journal-title":"Anal Biochem"},{"key":"10.1002\/jbm.b.33717-BIB0029|jbmb33717-cit-0030","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/0165-022X(84)90028-9","article-title":"Fourier Transform Infrared Reflection Absorption Spectroscopy (FT-IRAS) of fibrinogen adsorbed on metal and metal oxide surfaces","volume":"9","author":"Liedberg","year":"1984","journal-title":"J Biochem Biophys Methods"},{"key":"10.1002\/jbm.b.33717-BIB0030|jbmb33717-cit-0031","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1002\/jbm.a.30973","article-title":"Inflammatory response to titanium surfaces with fibrinogen and catalase coatings: An in vitro study","volume":"80","author":"Goransson","year":"2007","journal-title":"J Biomed Mater Res A"},{"key":"10.1002\/jbm.b.33717-BIB0031|jbmb33717-cit-0032","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1021\/mp5006118","article-title":"Carbodiimide induced cross-linking, ligand addition, and degradation in gelatin","volume":"12","author":"Cammarata","year":"2015","journal-title":"Mol Pharm"},{"key":"10.1002\/jbm.b.33717-BIB0032|jbmb33717-cit-0033","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/S0039-6028(01)01587-4","article-title":"Biomedical surface science: Foundations to frontiers","volume":"500","author":"Castner","year":"2002","journal-title":"Surf Sci"},{"key":"10.1002\/jbm.b.33717-BIB0033|jbmb33717-cit-0034","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1016\/S0142-9612(97)00029-X","article-title":"Cell and soft tissue interactions with methyl- and hydroxyl-terminated alkane thiols on gold surfaces","volume":"18","author":"Lindblad","year":"1997","journal-title":"Biomaterials"},{"key":"10.1002\/jbm.b.33717-BIB0034|jbmb33717-cit-0035","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/S0168-3659(03)00194-9","article-title":"Biodegradable microspheres for protein delivery","volume":"90","author":"Sinha","year":"2003","journal-title":"J Control Release"},{"key":"10.1002\/jbm.b.33717-BIB0035|jbmb33717-cit-0036","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1081\/PDT-100101402","article-title":"Stabilization of pH-induced degradation of porcine insulin in biodegradable polyester microspheres","volume":"4","author":"Shao","year":"1999","journal-title":"Pharm Dev Technol"}],"container-title":["Journal of Biomedical Materials Research Part B: Applied Biomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjbm.b.33717","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjbm.b.33717","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/jbm.b.33717","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,5]],"date-time":"2021-07-05T13:36:02Z","timestamp":1625492162000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbm.b.33717"}},"subtitle":["Insulin Released from Titanium Discs with Insulin Coatings"],"short-title":[],"issued":{"date-parts":[[2016,5,26]]},"references-count":35,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2017,10]]}},"URL":"https:\/\/doi.org\/10.1002\/jbm.b.33717","archive":["Portico"],"relation":{},"ISSN":["1552-4973"],"issn-type":[{"type":"print","value":"1552-4973"}],"subject":[],"published":{"date-parts":[[2016,5,26]]}}}