{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T09:14:08Z","timestamp":1790500448389,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2016,9,23]],"date-time":"2016-09-23T00:00:00Z","timestamp":1474588800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Biomed Mater Res"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Acellular xenogeneic tissues have the potential to provide \u2018off\u2010the\u2010shelf\u2019 grafts for anterior cruciate ligament (ACL) repair. To ensure that such grafts are sterile following packaging, it is desirable to use terminal sterilization methods. Here, the effects of gamma and electron beam irradiation on the biological and biomechanical properties of a previously developed acellular porcine superflexor tendon (pSFT) were investigated. Irradiation following treatment with peracetic acid was compared to peracetic acid treatment alone and the stability of grafts following long\u2010term storage assessed. Irradiation did not affect total collagen content or biocompatibility (determined using a contact cytotoxicity assay) of the grafts, but slightly increased the amount of denatured collagen in and decreased the thermal denaturation temperature of the tissue in a dose dependant fashion. Biomechanical properties of the grafts were altered by irradiation (reduced ultimate tensile strength and Young's modulus, increased failure strain), but remained superior to reported properties of the native human ACL. Long term storage at 4\u00b0C had no negative effects on the grafts. Of all the conditions tested, a dose of minimum 25\u00a0kGy of gamma irradiation had least effect on the grafts, suggesting that this dose produces a biocompatible pSFT graft with adequate mechanical properties for ACL repair. \u00a9 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 2477\u20132486, 2017.<\/jats:p>","DOI":"10.1002\/jbm.b.33786","type":"journal-article","created":{"date-parts":[[2016,9,23]],"date-time":"2016-09-23T14:17:39Z","timestamp":1474640259000},"page":"2477-2486","source":"Crossref","is-referenced-by-count":29,"title":["The effects of irradiation on the biological and biomechanical properties of an acellular porcine superflexor tendon graft for cruciate ligament repair"],"prefix":"10.1002","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4152-6140","authenticated-orcid":false,"given":"Jennifer H.","family":"Edwards","sequence":"first","affiliation":[{"name":"Institute of Medical and Biological Engineering University of Leeds Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Herbert","sequence":"additional","affiliation":[{"name":"Institute of Medical and Biological Engineering University of Leeds Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gemma L.","family":"Jones","sequence":"additional","affiliation":[{"name":"Institute of Medical and Biological Engineering University of Leeds Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iain W.","family":"Manfield","sequence":"additional","affiliation":[{"name":"School of Molecular and Cellular Biology University of Leeds Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Fisher","sequence":"additional","affiliation":[{"name":"Institute of Medical and Biological Engineering University of Leeds Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eileen","family":"Ingham","sequence":"additional","affiliation":[{"name":"Institute of Medical and Biological Engineering University of Leeds Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,9,23]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/0363546514542796"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.knee.2007.04.005"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/1941738111409890"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/jars.2001.19965"},{"issue":"3","key":"e_1_2_7_6_1","first-page":"394","article-title":"Bone\u2013patellar tendon\u2013bone versus soft\u2010tissue allograft for anterior cruciate ligament reconstruction: A systematic review","volume":"32","author":"Joyce CD","year":"2015","journal-title":"Arthroscopy"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-199605000-00010"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2004.09.033"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2014.0003"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2014.11.019"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10439-014-1103-8"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2011.01.057"},{"issue":"3","key":"e_1_2_7_13_1","first-page":"408","article-title":"In vitro assessment of the functional performance of the decellularized intact porcine aortic root","volume":"14","author":"Korossis SA","year":"2005","journal-title":"J Heart Valve Dis"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1089\/tea.2007.0233"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10561-012-9333-1"},{"issue":"17","key":"e_1_2_7_16_1","first-page":"2390","article-title":"The human tissue\u2010biomaterial interface: A role for PPARgamma\u2010dependentecellularizedreceptor activation in regulating the CD163+ M2 macrophage phenotype. 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