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Our aim is to combine optimal middle ear compatibility and surgical manageability in a single device, by releasing off\u2010the\u2010shelf homograft ORPs provided with the appealing features of synthetic ORPs, such as lightness, safety, measurement accuracy, surface decoration, and geometric plasticity. The new total ORP prototype was 13.1\u2009\u00b1\u20090.1 mg, leading to 81% weight reduction with respect to the previous model. Surface motifs of the head plate were applied to prevent slipping and migration after surgery, as shown by finite element modeling analysis. In addition, bone ORPs were provided with holed head plates to facilitate their surgical positioning while reducing their mass. A comparative measurement of acoustic responses of bone against synthetic partial ORPs in the 250\u20138000 Hz frequency range demonstrated their superior behavior. This study showed that banked compact bone can be optimally manufactured, eventually enabling the fabrication of light, standardized, and highly performant ORPs. The new bone ORPs may represent the ideal combination of biocompatibility and technology which can ultimately accomplish unmet otosurgical needs. \u00a9 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 2495\u20132506, 2017.<\/jats:p>","DOI":"10.1002\/jbm.b.33790","type":"journal-article","created":{"date-parts":[[2016,9,23]],"date-time":"2016-09-23T14:18:10Z","timestamp":1474640290000},"page":"2495-2506","source":"Crossref","is-referenced-by-count":16,"title":["Ossicular replacement prostheses from banked bone with ergonomic and functional geometry"],"prefix":"10.1002","volume":"105","author":[{"given":"Mario","family":"Milazzo","sequence":"first","affiliation":[{"name":"The BioRobotics Institute, Scuola Superiore Sant'Anna 56025 Pontedera (PI) Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8155-8537","authenticated-orcid":false,"given":"Serena","family":"Danti","sequence":"additional","affiliation":[{"name":"The BioRobotics Institute, Scuola Superiore Sant'Anna 56025 Pontedera (PI) Italy"},{"name":"Department of Civil and Industrial Engineering University of Pisa 56122 Pisa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Inglese","sequence":"additional","affiliation":[{"name":"The BioRobotics Institute, Scuola Superiore Sant'Anna 56025 Pontedera (PI) Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Godfried","family":"Jansen van Vuuren","sequence":"additional","affiliation":[{"name":"The BioRobotics Institute, Scuola Superiore Sant'Anna 56025 Pontedera (PI) Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vera","family":"Gramigna","sequence":"additional","affiliation":[{"name":"The BioRobotics Institute, Scuola Superiore Sant'Anna 56025 Pontedera (PI) Italy"},{"name":"Institute of Bioimaging and Molecular Physiology, National Research Council (CNR) 88100 Germaneto (CZ) Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriella","family":"Bonsignori","sequence":"additional","affiliation":[{"name":"The BioRobotics Institute, Scuola Superiore Sant'Anna 56025 Pontedera (PI) Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"De Vito","sequence":"additional","affiliation":[{"name":"Operative Unit of Otorhinolaryngology, Audiology and Phoniatrics Azienda Ospedaliero\u2010Universitaria Pisana (AOUP) 56124 Pisa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luca","family":"Bruschini","sequence":"additional","affiliation":[{"name":"Operative Unit of Otorhinolaryngology, Audiology and Phoniatrics Azienda Ospedaliero\u2010Universitaria Pisana (AOUP) 56124 Pisa Italy"},{"name":"Department of Surgical, Medical, Molecular Pathology and Emergency Medicine University of Pisa 56124 Pisa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cesare","family":"Stefanini","sequence":"additional","affiliation":[{"name":"The BioRobotics Institute, Scuola Superiore Sant'Anna 56025 Pontedera (PI) Italy"},{"name":"Department of Biomedical Engineering and Robotics Institute Khalifa University of Science Technology and Research, P.O. 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