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However, the uniform thin layer drug eluting coating on a stent not only inhibits the blood vessel's smooth muscle cell overgrowth but also delay the endotheliation process which is often associated with the occurrence of acute thrombosis. Therefore, in this study, we developed a novel coating method using PDLLA nanoparticles (NPs) as a coating to overcome this issue. The average 300 nm sized sirolimus\u2010loaded PDLLA nanoparticles were prepared by a conventional emulsion solvent evaporation method. A low temperature plasma polymerization technology to graft hydrophilic polymers on to poly (<jats:sc>l<\/jats:sc>\u2010lactide) stent was used to increase the surface coating efficiency of nanoparticles on the stent. Results showed that sirolimus\u2010loaded nanoparticles can be successfully coated on to the stents with sustained drug release properties.<jats:italic>In vitro<\/jats:italic>cell culture study showed the drug loaded nanoparticle coating effectively inhibited the proliferation of smooth muscle cells while still allowed a faster proliferation of endothelial cells, suggesting that the new NP coated bioresorbable stents have the potential to reduce both the occurrence of in\u2010stent restenosis and acute thrombosis. \u00a9 2016 Wiley Periodicals, Inc. 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