{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T17:31:22Z","timestamp":1788543082411,"version":"build-2803163510"},"reference-count":13,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,11,29]],"date-time":"2016-11-29T00:00:00Z","timestamp":1480377600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"The British Orthopaedic Association"},{"name":"DePuy International Ltd"},{"name":"Zimmer GmbH"},{"name":"Smith & Nephew UK Ltd"},{"name":"Biomet UK Ltd"},{"name":"JRI Ltd"},{"name":"Finsbury Orthopaedics Ltd"},{"DOI":"10.13039\/100012341","name":"Corin Group PLC","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100012341","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Mathys Orthopaedics Ltd"},{"name":"Stryker UK Ltd"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Biomed Mater Res"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Metal release in patients with joint replacements is associated with local tissue reactions, pain, and ultimately revision of implants. One of the causes of this metal loss is speculated to be due to a mechanism of inflammatory cell\u2010induced corrosion (ICIC).<\/jats:p><jats:p>In this knee retrieval study, we aimed to: (1) identify the extent and location of ICI corrosion patterns on our femoral and tibial components and (2) correlate our findings with implant and clinical information. We investigated 28 femoral and 9 tibial components made of polished CoCr for presence of ICIC, using macroscopic and microscopic screening and statistical analyses to identify any significant correlations between our results and clinical information.<\/jats:p><jats:p>We found that 71% of femoral and 100% of tibial components showed evidence of ICIC and significantly more was present on non\u2010contacting regions (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001). We found a significant correlation between the presence of ICIC and instability (<jats:italic>p<\/jats:italic>\u2009=\u20090.0113) and a significant difference between poster stabilized and cruciate retaining designs in the amount of ICIC on internal edges (<jats:italic>p<\/jats:italic>\u2009=\u20090.0375). This corrosion pattern was prevalent in our series of knee retrievals and may help explain some of the mechanisms of material loss that may occur<jats:italic>in vivo<\/jats:italic>. \u00a9 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 460\u2013467, 2018.<\/jats:p>","DOI":"10.1002\/jbm.b.33820","type":"journal-article","created":{"date-parts":[[2016,11,29]],"date-time":"2016-11-29T14:23:13Z","timestamp":1480429393000},"page":"460-467","source":"Crossref","is-referenced-by-count":26,"title":["Inflammatory cell\u2010induced corrosion in total knee arthroplasty: A retrieval study"],"prefix":"10.1002","volume":"106","author":[{"given":"Arianna","family":"Cerquiglini","sequence":"first","affiliation":[{"name":"Institute of Orthopaedics and Musculoskeletal Science, University College London and the Royal National Orthopaedic Hospital Stanmore United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johann","family":"Henckel","sequence":"additional","affiliation":[{"name":"Institute of Orthopaedics and Musculoskeletal Science, University College London and the Royal National Orthopaedic Hospital Stanmore United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harry S.","family":"Hothi","sequence":"additional","affiliation":[{"name":"Institute of Orthopaedics and Musculoskeletal Science, University College London and the Royal National Orthopaedic Hospital Stanmore United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Di Laura","sequence":"additional","affiliation":[{"name":"Institute of Orthopaedics and Musculoskeletal Science, University College London and the Royal National Orthopaedic Hospital Stanmore United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John A.","family":"Skinner","sequence":"additional","affiliation":[{"name":"Institute of Orthopaedics and Musculoskeletal Science, University College London and the Royal National Orthopaedic Hospital Stanmore United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alister J.","family":"Hart","sequence":"additional","affiliation":[{"name":"Institute of Orthopaedics and Musculoskeletal Science, University College London and the Royal National Orthopaedic Hospital Stanmore United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,11,29]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-199802000-00015"},{"issue":"1","key":"e_1_2_6_3_1","first-page":"1","article-title":"Requirement for successful total knee replacement. Material consideration","volume":"20","author":"Black J.","year":"1989","journal-title":"Orthop Clin N Am"},{"key":"e_1_2_6_4_1","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1002\/jbm.a.32627","article-title":"Soluble ions more than particulate cobalt\u2010alloy implant debris induce monocyte costimulatory molecule expression and release of profinflammatory cytokines critical to metla\u2010induced lymphocyte reactivity","volume":"93","author":"Caicedo MS","year":"2010","journal-title":"J Biomed Mater Res Part A"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/jclinpath-2011-200398"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.C.00949"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.1100150107"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-199807000-00003"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.35165"},{"key":"e_1_2_6_10_1","first-page":"000","article-title":"Clinical relevance of corrosion patterns attributed to inflammatory cell\u2010induced corrosion: A retrieval study","volume":"00","author":"Laura A","year":"2015","journal-title":"J Biomed Mater Res B Appl Biomater"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2016.05.006"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.32914"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.20831"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.820170510"}],"container-title":["Journal of Biomedical Materials Research Part B: Applied Biomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjbm.b.33820","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjbm.b.33820","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbm.b.33820","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,20]],"date-time":"2024-06-20T21:32:46Z","timestamp":1718919166000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbm.b.33820"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11,29]]},"references-count":13,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["10.1002\/jbm.b.33820"],"URL":"https:\/\/doi.org\/10.1002\/jbm.b.33820","archive":["Portico"],"relation":{},"ISSN":["1552-4973","1552-4981"],"issn-type":[{"value":"1552-4973","type":"print"},{"value":"1552-4981","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11,29]]}}}