{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:47:49Z","timestamp":1786978069070,"version":"build-2736575974"},"reference-count":75,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,7,4]],"date-time":"2017-07-04T00:00:00Z","timestamp":1499126400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004484","name":"Tehran University of Medical Sciences and Health Services","doi-asserted-by":"publisher","award":["95\u201301\u201087\u201331294"],"award-info":[{"award-number":["95\u201301\u201087\u201331294"]}],"id":[{"id":"10.13039\/501100004484","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Biomed Mater Res"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The current study aimed to enhance the efficacy of peripheral nerve regeneration using an electrically conductive biodegradable porous neural guidance conduit for transplantation of allogeneic Schwann cells (SCs). The conduit was produced from polylactic acid (PLA), multiwalled carbon nanotubes (MWCNTs), and gelatin nanofibrils (GNFs) coated with the recombinant human erythropoietin\u2010loaded chitosan nanoparticles (rhEpo\u2010CNPs). The PLA\/MWCNTs\/GNFs\/rhEpo\u2010CNPs conduit had the porosity of 85.78\u2009\u00b1\u20090.70%, the contact angle of 77.65\u2009\u00b1\u20091.91\u00b0 and the ultimate tensile strength and compressive modulus of 5.51\u2009\u00b1\u20090.13 MPa and 2.66\u2009\u00b1\u20090.34 MPa, respectively. The conduit showed the electrical conductivity of 0.32 S\u00a0cm\n                    <jats:sup>\u22121<\/jats:sup>\n                    and lost about 11% of its weight after 60 days in normal saline. The produced conduit was able to release the rhEpo for at least 2 weeks and exhibited favorable cytocompatibility towards SCs. For functional analysis, the conduit was seeded with 1.5 \u00d7 10\n                    <jats:sup>4<\/jats:sup>\n                    SCs and implanted into a 10 mm sciatic nerve defect of Wistar rat. After 14 weeks, the results of sciatic functional index, hot plate latency, compound muscle action potential amplitude, weight\u2010loss percentage of wet gastrocnemius muscle and Histopathological examination using hematoxylin\u2010eosin and Luxol fast blue staining demonstrated that the produced conduit had comparable nerve regeneration to the autograft, as the gold standard to bridge the nerve gaps. \u00a9 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 1463\u20131476, 2018.\n                  <\/jats:p>","DOI":"10.1002\/jbm.b.33952","type":"journal-article","created":{"date-parts":[[2017,7,4]],"date-time":"2017-07-04T11:19:55Z","timestamp":1499167195000},"page":"1463-1476","source":"Crossref","is-referenced-by-count":87,"title":["Sciatic nerve regeneration by transplantation of Schwann cells via erythropoietin controlled\u2010releasing polylactic acid\/multiwalled carbon nanotubes\/gelatin nanofibrils neural guidance conduit"],"prefix":"10.1002","volume":"106","author":[{"given":"Majid","family":"Salehi","sequence":"first","affiliation":[{"name":"Department of Tissue Engineering and Applied Cell Sciences School of Advanced Technologies in Medicine, Tehran University of Medical Sciences Tehran 1417755469 Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahdi","family":"Naseri\u2010Nosar","sequence":"additional","affiliation":[{"name":"Department of Tissue Engineering 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